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Isoxazole‐Derived Aroylhydrazones and Their Dinuclear Copper(II) Complexes Show Antiproliferative Activity on Breast Cancer Cells with a Potentially Alternative Mechanism Of Action

Abstract : Cytotoxicity contrast : Two aroylhydrazonic ligands and their acetate/perchlorate dicopper complexes were synthesized and characterized by various spectroscopic and analytical techniques, including X‐ray diffraction. They were shown to interact with DNA and display contrasted cytotoxicity on breast cancer cells. Their biological properties were linked to their ability to undergo chelation/transmetallation with biologically relevant metal ions.
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https://hal.sorbonne-universite.fr/hal-02749888
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Submitted on : Monday, December 7, 2020 - 1:17:58 PM
Last modification on : Wednesday, December 9, 2020 - 3:45:53 AM

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Jesica Paola Rada, Jéremy Forté, Geoffrey Gontard, Vincent Corce, Michèle Salmain, et al.. Isoxazole‐Derived Aroylhydrazones and Their Dinuclear Copper(II) Complexes Show Antiproliferative Activity on Breast Cancer Cells with a Potentially Alternative Mechanism Of Action. ChemBioChem, Wiley-VCH Verlag, 2020, 21 (17), pp.2474-2486. ⟨10.1002/cbic.202000122⟩. ⟨hal-02749888⟩

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