Sphingolipid Metabolism and Signaling in Skeletal Muscle: From Physiology to Physiopathology - Sorbonne Université Access content directly
Journal Articles Frontiers in Endocrinology Year : 2020

Sphingolipid Metabolism and Signaling in Skeletal Muscle: From Physiology to Physiopathology

Abstract

Sphingolipids represent one of the major classes of eukaryotic lipids. They play an essential structural role, especially in cell membranes where they also possess signaling properties and are capable of modulating multiple cell functions, such as apoptosis, cell proliferation, differentiation, and inflammation. Many sphingolipid derivatives, such as ceramide, sphingosine-1-phosphate, and ganglioside, have been shown to play many crucial roles in muscle under physiological and pathological conditions. This review will summarize our knowledge of sphingolipids and their effects on muscle fate, highlighting the role of this class of lipids in modulating muscle cell differentiation, regeneration, aging, response to insulin, and contraction. We show that modulating sphingolipid metabolism may be a novel and interesting way for preventing and/or treating several muscle-related diseases.
Fichier principal
Vignette du fichier
fendo-11-00491.pdf (2.08 Mo) Télécharger le fichier
Origin Publication funded by an institution
Loading...

Dates and versions

hal-02939128 , version 1 (15-09-2020)

Identifiers

Cite

Sophie Tan-Chen, Jeanne Guitton, Olivier Bourron, Hervé Le Stunff, Eric Hajduch. Sphingolipid Metabolism and Signaling in Skeletal Muscle: From Physiology to Physiopathology. Frontiers in Endocrinology, 2020, 11, pp.491. ⟨10.3389/fendo.2020.00491⟩. ⟨hal-02939128⟩
55 View
145 Download

Altmetric

Share

Gmail Mastodon Facebook X LinkedIn More