Skip to Main content Skip to Navigation
Journal articles

Iron Oxide Mediated Photothermal Therapy in the Second Biological Window: A Comparative Study between Magnetite/Maghemite Nanospheres and Nanoflowers

Abstract : The photothermal use of iron oxide magnetic nanoparticles (NPs) is becoming more and more popular and documented. Herein, we compared the photothermal (PT) therapy potential versus magnetic hyperthermia (MHT) modality of magnetic nanospheres, largely used in the biomedical field and magnetic multicore nanoflowers known among the best nanoheaters. The NPs were imaged using transmission electron microscopy and their optical properties characterized by UV-Vis-NIR-I-II before oxidation (magnetite) and after oxidation to maghemite. The efficiency of all NPs in MHT and PT in the preferred second near-infrared (NIR-II) biological window was carried out in water and in cancer cells. We show that, in water, magnetite nanoflowers are the most efficient nanoheaters for both modalities. Moreover, PT appears much more efficient than MHT at low NP dose, whatever the NP. In the cellular environment, for PT, efficiency was totally conserved, with magnetite nanoflowers as the best performers compared to MHT, which was totally lost. Finally, cell uptake was significantly increased for the nanoflowers compared to the nanospheres. Finally, the antitumor therapy was investigated for all NPs at the same dose delivered to the cancer cells and at reasonable laser power density (0.3 W/cm 2), which showed almost total cell death for magnetite nanoflowers.
Document type :
Journal articles
Complete list of metadata

Cited literature [44 references]  Display  Hide  Download

https://hal.sorbonne-universite.fr/hal-02942028
Contributor : Hal Sorbonne Université Gestionnaire <>
Submitted on : Thursday, September 17, 2020 - 3:09:56 PM
Last modification on : Friday, April 16, 2021 - 3:30:55 AM
Long-term archiving on: : Thursday, December 3, 2020 - 9:56:40 AM

File

nanomaterials-10-01548-v3.pdf
Publication funded by an institution

Identifiers

Citation

Sonia Cabana, Alberto Curcio, Aude Michel, Claire Wilhelm, Ali Abou-Hassan. Iron Oxide Mediated Photothermal Therapy in the Second Biological Window: A Comparative Study between Magnetite/Maghemite Nanospheres and Nanoflowers. Nanomaterials, MDPI, 2020, 10 (8), pp.1548. ⟨10.3390/nano10081548⟩. ⟨hal-02942028⟩

Share

Metrics

Record views

28

Files downloads

65