Genome-wide and candidate gene approaches of clopidogrel efficacy using pharmacodynamic and clinical end points—Rationale and design of the International Clopidogrel Pharmacogenomics Consortium (ICPC)

Thomas Bergmeijer; Jean-Luc Reny; Ruth Pakyz; Li Gong; Joshua Lewis; Eun-Young Kim; Daniel Aradi; Israel Fernandez-Cadenas; Richard Horenstein; Ming Ta Michael Lee; Ryan Whaley; Joan Montaner; Gian Franco Gensini; John Cleator; Kiyuk Chang; Lene Holmvang; Willibald Hochholzer; Dan Roden; Stefan Winter; Russ Altman; Dimitrios Alexopoulos; Ho-Sook Kim; Jean-Pierre Déry; Meinrad Gawaz; Kevin Bliden; Marco Valgimigli; Rossella Marcucci; Gianluca Campo; Elke Schaeffeler; Nadia Dridi; Ming-Shien Wen; Jae Gook Shin; Tabassome Simon; Pierre Fontana; Betti Giusti; Tobias Geisler; Michiaki Kubo; Dietmar Trenk; Jolanta Siller-Matula; Jurriën ten Berg; Paul Gurbel; Jean-Sebastien Hulot; Braxton Mitchell; Matthias Schwab; Marylyn Deriggi Ritchie; Teri Klein; Alan Shuldiner

doi:10.1016/j.ahj.2017.12.010

Journal Articles American Heart Journal Year : 2018

Genome-wide and candidate gene approaches of clopidogrel efficacy using pharmacodynamic and clinical end points—Rationale and design of the International Clopidogrel Pharmacogenomics Consortium (ICPC)

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Thomas Bergmeijer

Function : Author

Jean-Luc Reny

Function : Author

Ruth Pakyz

Function : Author

Li Gong

Function : Author

Joshua Lewis

Function : Author

Eun-Young Kim

Function : Author

Daniel Aradi

Function : Author

Israel Fernandez-Cadenas

Function : Author

Richard Horenstein

Function : Author

Ming Ta Michael Lee

Function : Author

Ryan Whaley

Function : Author

Joan Montaner

Function : Author

Gian Franco Gensini

Function : Author

John Cleator

Function : Author

Kiyuk Chang

Function : Author

Lene Holmvang

Function : Author

Willibald Hochholzer

Function : Author

Dan Roden

Function : Author

Stefan Winter

Function : Author

Russ Altman

Function : Author

Dimitrios Alexopoulos

Function : Author

Ho-Sook Kim

Function : Author

Jean-Pierre Déry

Function : Author

Meinrad Gawaz

Function : Author

Kevin Bliden

Function : Author

Marco Valgimigli

Function : Author
PersonId : 781323
ORCID : 0000-0002-4353-7110

Rossella Marcucci

Function : Author

Gianluca Campo

Function : Author

Elke Schaeffeler

Function : Author

Nadia Dridi

Function : Author

Ming-Shien Wen

Function : Author

Jae Gook Shin

Function : Author

Tabassome Simon

Function : Author
PersonId : 741176
IdHAL : tabassome-simon
ORCID : 0000-0002-4550-0450
IdRef : 070443122

Centre de Ressources Biologiques HUEP-UPMC

Pierre Fontana

Function : Author

Betti Giusti

Function : Author

Tobias Geisler

Function : Author

Michiaki Kubo

Function : Author

Dietmar Trenk

Function : Author

Jolanta Siller-Matula

Function : Author

Jurriën ten Berg

Function : Author

Paul Gurbel

Function : Author

Jean-Sebastien Hulot

Function : Author

Braxton Mitchell

Function : Author

Matthias Schwab

Function : Author

Marylyn Deriggi Ritchie

Function : Author

Teri Klein

Function : Author

Alan Shuldiner

Function : Author

Abstract

The P2Y12 receptor inhibitor clopidogrel is widely used in patients with acute coronary syndrome, percutaneous coronary intervention, or ischemic stroke. Platelet inhibition by clopidogrel shows wide interpatient variability, and high on-treatment platelet reactivity is a risk factor for atherothrombotic events, particularly in high-risk populations. CYP2C19 polymorphism plays an important role in this variability, but heritability estimates suggest that additional genetic variants remain unidentified. The aim of the International Clopidogrel Pharmacogenomics Consortium (ICPC) is to identify genetic determinants of clopidogrel pharmacodynamics and clinical response.

Domains

Neurobiology Biotechnology Biochemistry [q-bio.BM]

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https://hal.sorbonne-universite.fr/hal-03025815

Submitted on : Thursday, November 26, 2020-2:17:03 PM

Last modification on : Tuesday, June 20, 2023-11:03:36 AM

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hal-03025815 , version 1 (26-11-2020)

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HAL Id : hal-03025815 , version 1
DOI : 10.1016/j.ahj.2017.12.010
PUBMED : 29653637
PUBMEDCENTRAL : PMC5903579

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Thomas Bergmeijer, Jean-Luc Reny, Ruth Pakyz, Li Gong, Joshua Lewis, et al.. Genome-wide and candidate gene approaches of clopidogrel efficacy using pharmacodynamic and clinical end points—Rationale and design of the International Clopidogrel Pharmacogenomics Consortium (ICPC). American Heart Journal, 2018, 198, pp.152-159. ⟨10.1016/j.ahj.2017.12.010⟩. ⟨hal-03025815⟩

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Genome-wide and candidate gene approaches of clopidogrel efficacy using pharmacodynamic and clinical end points—Rationale and design of the International Clopidogrel Pharmacogenomics Consortium (ICPC)

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