Genome-wide and candidate gene approaches of clopidogrel efficacy using pharmacodynamic and clinical end points—Rationale and design of the International Clopidogrel Pharmacogenomics Consortium (ICPC)
Thomas Bergmeijer
,
Jean-Luc Reny
,
Ruth Pakyz
,
Li Gong
,
Joshua Lewis
,
Eun-Young Kim
,
Daniel Aradi
,
Israel Fernandez-Cadenas
,
Richard Horenstein
,
Ming Ta Michael Lee
,
Ryan Whaley
,
Joan Montaner
,
Gian Franco Gensini
,
John Cleator
,
Kiyuk Chang
,
Lene Holmvang
,
Willibald Hochholzer
,
Dan Roden
,
Stefan Winter
,
Russ Altman
,
Dimitrios Alexopoulos
,
Ho-Sook Kim
,
Jean-Pierre Déry
,
Meinrad Gawaz
,
Kevin Bliden
,
Marco Valgimigli
,
Rossella Marcucci
,
Gianluca Campo
,
Elke Schaeffeler
,
Nadia Dridi
,
Ming-Shien Wen
,
Jae Gook Shin
,
Tabassome Simon
(1)
,
Pierre Fontana
,
Betti Giusti
,
Tobias Geisler
,
Michiaki Kubo
,
Dietmar Trenk
,
Jolanta Siller-Matula
,
Jurriën ten Berg
,
Paul Gurbel
,
Jean-Sebastien Hulot
,
Braxton Mitchell
,
Matthias Schwab
,
Marylyn Deriggi Ritchie
,
Teri Klein
,
Alan Shuldiner
Thomas Bergmeijer
- Function : Author
Jean-Luc Reny
- Function : Author
Ruth Pakyz
- Function : Author
Li Gong
- Function : Author
Joshua Lewis
- Function : Author
Eun-Young Kim
- Function : Author
Daniel Aradi
- Function : Author
Israel Fernandez-Cadenas
- Function : Author
Richard Horenstein
- Function : Author
Ming Ta Michael Lee
- Function : Author
Ryan Whaley
- Function : Author
Joan Montaner
- Function : Author
Gian Franco Gensini
- Function : Author
John Cleator
- Function : Author
Kiyuk Chang
- Function : Author
Lene Holmvang
- Function : Author
Willibald Hochholzer
- Function : Author
Dan Roden
- Function : Author
Stefan Winter
- Function : Author
Russ Altman
- Function : Author
Dimitrios Alexopoulos
- Function : Author
Ho-Sook Kim
- Function : Author
Jean-Pierre Déry
- Function : Author
Meinrad Gawaz
- Function : Author
Kevin Bliden
- Function : Author
Marco Valgimigli
- Function : Author
- PersonId : 781323
- ORCID : 0000-0002-4353-7110
Rossella Marcucci
- Function : Author
Gianluca Campo
- Function : Author
Elke Schaeffeler
- Function : Author
Nadia Dridi
- Function : Author
Ming-Shien Wen
- Function : Author
Jae Gook Shin
- Function : Author
Tabassome Simon
- Function : Author
- PersonId : 741176
- IdHAL : tabassome-simon
- ORCID : 0000-0002-4550-0450
- IdRef : 070443122
Pierre Fontana
- Function : Author
Betti Giusti
- Function : Author
Tobias Geisler
- Function : Author
Michiaki Kubo
- Function : Author
Dietmar Trenk
- Function : Author
Jolanta Siller-Matula
- Function : Author
Jurriën ten Berg
- Function : Author
Paul Gurbel
- Function : Author
Jean-Sebastien Hulot
- Function : Author
Braxton Mitchell
- Function : Author
Matthias Schwab
- Function : Author
Marylyn Deriggi Ritchie
- Function : Author
Teri Klein
- Function : Author
Alan Shuldiner
- Function : Author
Abstract
The P2Y12 receptor inhibitor clopidogrel is widely used in patients with acute coronary syndrome, percutaneous coronary intervention, or ischemic stroke. Platelet inhibition by clopidogrel shows wide interpatient variability, and high on-treatment platelet reactivity is a risk factor for atherothrombotic events, particularly in high-risk populations. CYP2C19 polymorphism plays an important role in this variability, but heritability estimates suggest that additional genetic variants remain unidentified. The aim of the International Clopidogrel Pharmacogenomics Consortium (ICPC) is to identify genetic determinants of clopidogrel pharmacodynamics and clinical response.