Imaging resident and recruited macrophage contribution to Wallerian degeneration - Sorbonne Université
Article Dans Une Revue Journal of Experimental Medicine Année : 2020

Imaging resident and recruited macrophage contribution to Wallerian degeneration

Résumé

Wallerian degeneration (WD) is a process of autonomous distal degeneration of axons upon injury. Macrophages (MPs) of the peripheral nervous system (PNS) are the main cellular agent controlling this process. Some evidence suggests that resident PNS-MPs along with MPs of hematogenous origin may be involved, but whether these two subsets exert distinct functions is unknown. Combining MP-designed fluorescent reporter mice and coherent anti-Stokes Raman scattering (CARS) imaging of the sciatic nerve, we deciphered the spatiotemporal choreography of resident and recently recruited MPs after injury and unveiled distinct functions of these subsets, with recruited MPs being responsible for efficient myelin stripping and clearance and resident MPs being involved in axonal regrowth. This work provides clues to tackle selectively cellular processes involved in neurodegenerative diseases.
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Dates et versions

hal-03047020 , version 1 (08-12-2020)

Identifiants

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Alexandre Boissonnas, Floriane Louboutin, Marie Laviron, Pierre-Louis Loyher, Elodie Reboussin, et al.. Imaging resident and recruited macrophage contribution to Wallerian degeneration. Journal of Experimental Medicine, 2020, 217 (11), ⟨10.1084/jem.20200471⟩. ⟨hal-03047020⟩
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