Single-cell Study of Two Rat Models of Pulmonary Arterial Hypertension Reveals Connections to Human Pathobiology and Drug Repositioning - Sorbonne Université

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Journal Articles American Journal of Respiratory and Critical Care Medicine Year : 2020

Single-cell Study of Two Rat Models of Pulmonary Arterial Hypertension Reveals Connections to Human Pathobiology and Drug Repositioning

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Jason Hong

Function : Author

University of California [Los Angeles]

Douglas Arneson

Function : Author

University of California [Los Angeles]

Soban Umar

Function : Author

University of California [Los Angeles]

Gregoire Ruffenach

Function : Author

University of California [Los Angeles]

Christine Cunningham

Function : Author

University of California [Los Angeles]

In Sook Ahn

Function : Author

University of California [Los Angeles]

Graciel Diamante

Function : Author

University of California [Los Angeles]

May Bhetraratana

Function : Author

University of California [Los Angeles]

John Park

Function : Author

University of California [Los Angeles]

Emma Said

Function : Author

University of California [Los Angeles]

Caroline Huynh

Function : Author

University of California [Los Angeles]

Trixie Le

Function : Author

University of California [Los Angeles]

Lejla Medzikovic

Function : Author

University of California [Los Angeles]

Marc Humbert

Function : Author
PersonId : 756837
ORCID : 0000-0003-0703-2892
IdRef : 071559426

University of California [Los Angeles]

Hypertension pulmonaire : physiopathologie et innovation thérapeutique

Florent Soubrier

Function : Author
PersonId : 777749
ORCID : 0000-0003-2571-7932
IdRef : 069711348

Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases

David Montani

Function : Author
PersonId : 765451
ORCID : 0000-0002-9358-6922
IdRef : 092632580

Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre]

Hypertension pulmonaire : physiopathologie et innovation thérapeutique

Barbara Girerd

Function : Author

AP-HP - Hôpital Antoine Béclère [Clamart]

Hypertension pulmonaire : physiopathologie et innovation thérapeutique

David-Alexandre Trégouët

Function : Author

University of California [Los Angeles]

Bordeaux population health

Richard Channick

Function : Author

University of California [Los Angeles]

Rajan Saggar

Function : Author

University of California [Los Angeles]

Mansoureh Eghbali

Function : Author

University of California [Los Angeles]

Xia Yang

Function : Author
PersonId : 735244
IdHAL : yang-xia
ORCID : 0000-0001-9842-030X
IdRef : 237727234

University of California [Los Angeles]

Abstract

The cellular and molecular landscape and translational value of commonly used models of pulmonary arterial hypertension (PAH) are poorly understood. Single-cell transcriptomics can enhance molecular understanding of preclinical models and facilitate their rational use and interpretation.

Keywords

Sugen-hypoxia drug repurposing monocrotaline pulmonary hypertension scRNA-seq

Domains

Human health and pathology

Gestionnaire HAL 3 Sorbonne Université : Connect in order to contact the contributor

https://hal.sorbonne-universite.fr/hal-03104014

Submitted on : Friday, January 8, 2021-3:36:05 PM

Last modification on : Sunday, April 14, 2024-3:11:01 AM

Dates and versions

hal-03104014 , version 1 (08-01-2021)

Identifiers

HAL Id : hal-03104014 , version 1
DOI : 10.1164/rccm.202006-2169OC
PUBMED : 33021809
PUBMEDCENTRAL : PMC8048757

Cite

Jason Hong, Douglas Arneson, Soban Umar, Gregoire Ruffenach, Christine Cunningham, et al.. Single-cell Study of Two Rat Models of Pulmonary Arterial Hypertension Reveals Connections to Human Pathobiology and Drug Repositioning. American Journal of Respiratory and Critical Care Medicine, 2020, ⟨10.1164/rccm.202006-2169OC⟩. ⟨hal-03104014⟩

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ICAN UNIV-PARIS-SACLAY SORBONNE-UNIVERSITE SU-MEDECINE U1219 GS-LIFE-SCIENCES-HEALTH GS-HEALTH-DRUG-SCIENCES IHU_ICAN HPPIT

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