Single-cell Study of Two Rat Models of Pulmonary Arterial Hypertension Reveals Connections to Human Pathobiology and Drug Repositioning - Sorbonne Université
Journal Articles American Journal of Respiratory and Critical Care Medicine Year : 2020

Single-cell Study of Two Rat Models of Pulmonary Arterial Hypertension Reveals Connections to Human Pathobiology and Drug Repositioning

Xia Yang

Abstract

The cellular and molecular landscape and translational value of commonly used models of pulmonary arterial hypertension (PAH) are poorly understood. Single-cell transcriptomics can enhance molecular understanding of preclinical models and facilitate their rational use and interpretation.

Dates and versions

hal-03104014 , version 1 (08-01-2021)

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Jason Hong, Douglas Arneson, Soban Umar, Gregoire Ruffenach, Christine Cunningham, et al.. Single-cell Study of Two Rat Models of Pulmonary Arterial Hypertension Reveals Connections to Human Pathobiology and Drug Repositioning. American Journal of Respiratory and Critical Care Medicine, 2020, ⟨10.1164/rccm.202006-2169OC⟩. ⟨hal-03104014⟩
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