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Progress regarding the context-of-use of tau as biomarker of Alzheimer’s disease and other neurodegenerative diseases

Abstract : Introduction: Tau protein misfolding and accumulation in toxic species is a critical pathophysiological process of Alzheimer's Disease (AD) and other neurodegenerative disorders (NDDs). Tau biomarkers, namely cerebrospinal fluid (CSF) total-tau (t-tau), 181-phosphorylated tau (p-tau) and tau-PET tracers, have been recently embedded in the diagnostic criteria for AD. Nevertheless, the role of tau as a diagnostic and prognostic biomarker for other NDDs remains controversial. Areas covered: We performed a systematical PubMed-based review of the most recent advances in tau-related biomarkers for NDDs. We focused on papers published from 2015 to 2020 assessing the diagnostic or prognostic value of each biomarker. Expert opinion: The assessment of tau biomarkers in alternative easily accessible matrices, through the development of ultrasensitive techniques, represents the most significant perspective for AD-biomarker research. In NDDs, novel tau isoforms (e.g., p-tau217) or proteolytic fragments (e.g., N-terminal fragments) may represent candidate diagnostic and prognostic biomarkers and may help monitoring disease progression. Protein misfolding amplification assays, allowing the identification of different tau strains (e.g. 3R- vs. 4R-tau) in CSF, may constitute a breakthrough for the in vivo stratification of NDDs. Tau-PET may help tracking the spatial-temporal evolution of tau pathophysiology in AD but its application outside the AD-spectrum deserves further studies.
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https://hal.sorbonne-universite.fr/hal-03138524
Contributor : Gestionnaire Hal-Su <>
Submitted on : Thursday, February 11, 2021 - 11:08:35 AM
Last modification on : Saturday, February 13, 2021 - 3:29:02 AM

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Nicole Campese, Giovanni Palermo, Claudia Del Gamba, Maria Francesca Beatino, Alessandro Galgani, et al.. Progress regarding the context-of-use of tau as biomarker of Alzheimer’s disease and other neurodegenerative diseases. Expert Review of Proteomics, Taylor & Francis, 2021, ⟨10.1080/14789450.2021.1886929⟩. ⟨hal-03138524⟩

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