The first ocydromiine hybotid fly is described and illustrated from a remarkable male preserved in mid-Cretaceous amber from northern Myanmar. Pouillonhybos venator, gen. et sp. nov., is distinguished from other members of the subfamily Ocydromiinae as well as other lineages of living and fossil Hybotidae. The holotype of P. venator exhibits spectacular specializations of the mid and hind legs, modifications likely linked to the grasping of prey either during capture and/or while feeding. The species reported here is the earliest evidence of significant leg modifications in Hybotidae indicating an early appearance of such specializations in the family's history.