SARS-CoV-2 infection in patients with primary central nervous system lymphoma - Sorbonne Université Accéder directement au contenu
Article Dans Une Revue Journal of Neurology Année : 2021

SARS-CoV-2 infection in patients with primary central nervous system lymphoma

Valérie Pourcher

Résumé

Background Cancer patients may be at higher risk for severe coronavirus infectious disease-19 (COVID-19); however, the outcome of Primary Central Nervous System Lymphoma (PCNSL) patients with SARS-CoV-2 infection has not been described yet. Methods We conducted a retrospective study within the Lymphomes Oculo-Cérébraux national network (LOC) to assess the clinical characteristics and outcome of SARS-CoV-2 infection in PCNSL patients (positive real-time polymerase chain reaction of nasopharyngeal swab or evocative lung computed tomography scan). We compared clinical characteristics between patients with severe (death and/or intensive care unit admission) and mild disease. Results Between March and May 2020, 13 PCNSL patients were diagnosed with SARS-CoV-2 infection, 11 (85%) of whom were undergoing chemotherapy at the time of infection. The mortality rate was 23% (3/13), and two additional patients (15%) required mechanical ventilation. Two patients (15%) had no COVID-19 symptoms. History of diabetes mellitus was more common in severe patients (3/5 vs 0/8, p = 0.03). Two patients recovered from COVID-19 after mechanical ventilation during more than two weeks and resumed chemotherapy. In all, chemotherapy was resumed after COVID-19 recovery in nine patients (69%) after a median delay of 16 days (range 3-32), none of whom developed unusual chemotherapy complication nor SARS-Cov2 reactivation. Conclusion This preliminary analysis suggests that, while being at higher risk be for severe illness, PCNSL patients with COVID-19 might be treated maximally especially if they achieved oncological response at the time of SARS-CoV-2 infection. Chemotherapy might be resumed without prolonged delay in PCNSL patients with COVID-19.

Domaines

Virologie
Fichier principal
Vignette du fichier
Laurenge2021_Article_SARS-CoV-2InfectionInPatientsW.pdf (2.57 Mo) Télécharger le fichier
Origine : Publication financée par une institution

Dates et versions

hal-03146856 , version 1 (19-02-2021)

Licence

Paternité - Pas d'utilisation commerciale

Identifiants

Citer

Alice Laurenge, Renata Ursu, Caroline Houillier, Basma Abdi, Gianpiero Tebano, et al.. SARS-CoV-2 infection in patients with primary central nervous system lymphoma. Journal of Neurology, 2021, ⟨10.1007/s00415-020-10311-w⟩. ⟨hal-03146856⟩
71 Consultations
66 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More