Anatomical dissociation of intracerebral signals for reward and punishment prediction errors in humans - Sorbonne Université Accéder directement au contenu
Article Dans Une Revue Nature Communications Année : 2021

Anatomical dissociation of intracerebral signals for reward and punishment prediction errors in humans

Résumé

Whether maximizing rewards and minimizing punishments rely on distinct brain systems remains debated, given inconsistent results coming from human neuroimaging and animal electrophysiology studies. Bridging the gap across techniques, we recorded intracerebral activity from twenty participants while they performed an instrumental learning task. We found that both reward and punishment prediction errors (PE), estimated from computational modeling of choice behavior, correlate positively with broadband gamma activity (BGA) in several brain regions. In all cases, BGA scaled positively with the outcome (reward or punishment versus nothing) and negatively with the expectation (predictability of reward or punishment). However, reward PE were better signaled in some regions (such as the ventromedial prefrontal and lateral orbitofrontal cortex), and punishment PE in other regions (such as the anterior insula and dorsolateral prefrontal cortex). These regions might therefore belong to brain systems that differentially contribute to the repetition of rewarded choices and the avoidance of punished choices.
Whether maximizing rewards and minimizing punishments rely on distinct brain systems remains debated, given inconsistent results coming from human neuroimaging and animal electrophysiology studies. Bridging the gap across techniques, we recorded intracerebral activity from twenty participants while they performed an instrumental learning task. We found that both reward and punishment prediction errors (PE), estimated from computational modeling of choice behavior, correlate positively with broadband gamma activity (BGA) in several brain regions. In all cases, BGA scaled positively with the outcome (reward or punishment versus nothing) and negatively with the expectation (predictability of reward or punishment). However, reward PE were better signaled in some regions (such as the ventromedial prefrontal and lateral orbitofrontal cortex), and punishment PE in other regions (such as the anterior insula and dorsolateral prefrontal cortex). These regions might therefore belong to brain systems that differentially contribute to the repetition of rewarded choices and the avoidance of punished choices.
Fichier principal
Vignette du fichier
s41467-021-23704-w.pdf (2.52 Mo) Télécharger le fichier
Origine : Publication financée par une institution

Dates et versions

hal-03256527 , version 1 (10-06-2021)

Identifiants

Citer

Maëlle C M Gueguen, Alizée Lopez-Persem, Pablo Billeke, Jean-Philippe Lachaux, Sylvain Rheims, et al.. Anatomical dissociation of intracerebral signals for reward and punishment prediction errors in humans. Nature Communications, 2021, 12 (1), ⟨10.1038/s41467-021-23704-w⟩. ⟨hal-03256527⟩
40 Consultations
36 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More