DMTs and Covid‐19 severity in MS: a pooled analysis from Italy and France
Maria Pia Sormani
(1)
,
Marco Salvetti
(2)
,
Pierre Labauge
(3)
,
Irene Schiavetti
(1)
,
Helene Zephir
(4)
,
Luca Carmisciano
(1)
,
Caroline Bensa
(5)
,
Nicola de Rossi
(6)
,
Jean Pelletier
(7)
,
Cinzia Cordioli
(6)
,
Sandra Vukusic
(8)
,
Lucia Moiola
(9)
,
Philippe Kerschen
(10)
,
Marta Radaelli
(11)
,
Marie Théaudin
(12)
,
Paolo Immovilli
,
Olivier Casez
(13)
,
Marco Capobianco
,
Jonathan Ciron
(14)
,
Maria Trojano
(15)
,
Bruno Stankoff
(16, 17)
,
Alain Créange
(18)
,
Gioacchino Tedeschi
(19)
,
Pierre Clavelou
(20)
,
Giancarlo Comi
(9)
,
Eric Thouvenot
(21, 22)
,
Mario Alberto Battaglia
(23)
,
Thibault Moreau
(24)
,
Francesco Patti
(25)
,
Jérôme de Sèze
(26)
,
Celine Louapre
(16, 27)
1
UniGe -
Università degli studi di Genova = University of Genoa
2 UNIROMA - Università degli Studi di Roma "La Sapienza" = Sapienza University [Rome]
3 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
4 LilNCog - Lille Neurosciences & Cognition - U 1172
5 Fondation Ophtalmologique Adolphe de Rothschild [Paris]
6 Azienda Socio Sanitaria Territoriale Spedali Civili di Brescia [Brescia]
7 TIMONE - Hôpital de la Timone [CHU - APHM]
8 HCL - Hospices Civils de Lyon
9 IRCCS Ospedale San Raffaele [Milan, Italy]
10 CHL - Centre Hospitalier de Luxembourg [Luxembourg]
11 Azienda Ospedaliera Ospedale Papa Giovanni XXIII [Bergamo, Italy]
12 UNIL - Université de Lausanne = University of Lausanne
13 CHUGA - Centre Hospitalier Universitaire [CHU Grenoble]
14 CHU Toulouse - Centre Hospitalier Universitaire de Toulouse
15 UNIBA - Università degli studi di Bari Aldo Moro = University of Bari Aldo Moro
16 ICM - Institut du Cerveau = Paris Brain Institute
17 CHU Saint-Antoine [AP-HP]
18 Service de neurologie [Mondor]
19 Università degli studi della Campania "Luigi Vanvitelli" = University of the Study of Campania Luigi Vanvitelli
20 CHU Clermont-Ferrand
21 CHU Nîmes - Centre Hospitalier Universitaire de Nîmes
22 IGF - Institut de Génomique Fonctionnelle
23 UNISI - Università degli Studi di Siena = University of Siena
24 CHU Dijon - Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand
25 Unict - Università degli studi di Catania = University of Catania
26 Centre d’Investigation Clinique Plurithématique (CIC - P) - CIC Strasbourg
27 CIC Neurosciences - Centre d'investigation clinique Neurosciences [CHU Pitié Salpêtrière]
2 UNIROMA - Università degli Studi di Roma "La Sapienza" = Sapienza University [Rome]
3 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
4 LilNCog - Lille Neurosciences & Cognition - U 1172
5 Fondation Ophtalmologique Adolphe de Rothschild [Paris]
6 Azienda Socio Sanitaria Territoriale Spedali Civili di Brescia [Brescia]
7 TIMONE - Hôpital de la Timone [CHU - APHM]
8 HCL - Hospices Civils de Lyon
9 IRCCS Ospedale San Raffaele [Milan, Italy]
10 CHL - Centre Hospitalier de Luxembourg [Luxembourg]
11 Azienda Ospedaliera Ospedale Papa Giovanni XXIII [Bergamo, Italy]
12 UNIL - Université de Lausanne = University of Lausanne
13 CHUGA - Centre Hospitalier Universitaire [CHU Grenoble]
14 CHU Toulouse - Centre Hospitalier Universitaire de Toulouse
15 UNIBA - Università degli studi di Bari Aldo Moro = University of Bari Aldo Moro
16 ICM - Institut du Cerveau = Paris Brain Institute
17 CHU Saint-Antoine [AP-HP]
18 Service de neurologie [Mondor]
19 Università degli studi della Campania "Luigi Vanvitelli" = University of the Study of Campania Luigi Vanvitelli
20 CHU Clermont-Ferrand
21 CHU Nîmes - Centre Hospitalier Universitaire de Nîmes
22 IGF - Institut de Génomique Fonctionnelle
23 UNISI - Università degli Studi di Siena = University of Siena
24 CHU Dijon - Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand
25 Unict - Università degli studi di Catania = University of Catania
26 Centre d’Investigation Clinique Plurithématique (CIC - P) - CIC Strasbourg
27 CIC Neurosciences - Centre d'investigation clinique Neurosciences [CHU Pitié Salpêtrière]
Maria Pia Sormani
- Fonction : Auteur
- PersonId : 1105093
Pierre Labauge
- Fonction : Auteur
- PersonId : 759958
- ORCID : 0000-0001-7759-8555
- IdRef : 059860367
Jean Pelletier
- Fonction : Auteur
- PersonId : 756935
- ORCID : 0000-0001-9730-7567
- IdRef : 078804868
Sandra Vukusic
- Fonction : Auteur
- PersonId : 740274
- IdHAL : adil-maarouf
- ORCID : 0000-0002-6755-496X
- IdRef : 164833250
Paolo Immovilli
- Fonction : Auteur
Marco Capobianco
- Fonction : Auteur
Jonathan Ciron
- Fonction : Auteur
- PersonId : 795646
- ORCID : 0000-0002-3386-6308
- IdRef : 137599021
Bruno Stankoff
- Fonction : Auteur
- PersonId : 1146488
- ORCID : 0000-0002-9631-4674
- IdRef : 070067988
Eric Thouvenot
- Fonction : Auteur
- PersonId : 1037455
Résumé
We evaluated the effect of DMTs on Covid-19 severity in patients with MS, with a pooled-analysis of two large cohorts from Italy and France. The association of baseline characteristics and DMTs with Covid-19 severity was assessed by multivariate ordinal-logistic models and pooled by a fixed-effect meta-analysis. 1066 patients with MS from Italy and 721 from France were included. In the multivariate model, anti-CD20 therapies were significantly associated (OR = 2.05, 95%CI = 1.39-3.02, p < 0.001) with Covid-19 severity, whereas interferon indicated a decreased risk (OR = 0.42, 95%CI = 0.18-0.99, p = 0.047). This pooled-analysis confirms an increased risk of severe Covid-19 in patients on anti-CD20 therapies and supports the protective role of interferon.
Origine : Publication financée par une institution