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Hydraulic and electric control of cell spheroids

Abstract : We use a theoretical approach to examine the effect of a radial fluid flow or electric current on the growth and homeostasis of a cell spheroid. Such conditions may be generated by a drain of micrometric diameter. To perform this analysis, we describe the tissue as a continuum. We include active mechanical, electric, and hydraulic components in the tissue material properties. We consider a spherical geometry and study the effect of the drain on the dynamics of the cell aggregate. We show that a steady fluid flow or electric current imposed by the drain could be able to significantly change the spheroid long-time state. In particular, our work suggests that a growing spheroid can systematically be driven to a shrinking state if an appropriate external field is applied. Order-of-magnitude estimates suggest that such fields are of the order of the indigenous ones. Similarities and differences with the case of tumors and embryo development are briefly discussed.
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Submitted on : Tuesday, October 12, 2021 - 9:40:01 AM
Last modification on : Tuesday, January 4, 2022 - 6:06:14 AM
Long-term archiving on: : Thursday, January 13, 2022 - 6:32:55 PM

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Charlie Duclut, Jacques Prost, Frank Jülicher. Hydraulic and electric control of cell spheroids. Proceedings of the National Academy of Sciences of the United States of America , National Academy of Sciences, 2021, 118 (19), pp.e2021972118. ⟨10.1073/pnas.2021972118⟩. ⟨hal-03374350⟩

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