RAFT-polymerized N-cyanomethylacrylamide-based (co)polymers exhibiting tunable UCST behavior in water - Sorbonne Université
Journal Articles Macromolecular Rapid Communications Year : 2021

RAFT-polymerized N-cyanomethylacrylamide-based (co)polymers exhibiting tunable UCST behavior in water

Abstract

In this present work, the synthesis of a new family of upper critical solution temperature (UCST)-thermoresponsive polymers based on N-cyanomethylacrylamide (CMAm) is reported. It is demonstrated that the thermally initiated reversible addition fragmentation chain transfer (RAFT) polymerization of CMAm conducted in N,N-dimethylformamide (DMF) is well controlled. The homopolymer presents a sharp and reversible UCST-type phase transition in pure water with a very small hysteresis between cooling and heating cycles. It is demonstrated that the cloud point (TCP) of poly(N-cyanomethylacrylamide) (PCMAm) is strongly molar mass dependent and shifts toward lower temperatures in saline water. Moreover, the transition temperature can be tuned over a large temperature range by copolymerization of CMAm with acrylamide or acrylic acid. The latter copolymers are both thermoresponsive and pH responsive. Interestingly, by this strategy sharp and reversible UCST-type transitions close to physiological temperature can be reached, which makes the copolymers extremely interesting candidates for biomedical applications.
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Dates and versions

hal-03388766 , version 1 (20-10-2021)

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Nicolas Audureau, Clémence Veith, Fanny Coumes, Thi Phuong Thu Nguyen, Jutta Rieger, et al.. RAFT-polymerized N-cyanomethylacrylamide-based (co)polymers exhibiting tunable UCST behavior in water. Macromolecular Rapid Communications, 2021, pp.2100556. ⟨10.1002/marc.202100556⟩. ⟨hal-03388766⟩
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