Identifying early indicators of secondary peritonitis in critically ill patients with cirrhosis - Sorbonne Université
Article Dans Une Revue Scientific Reports Année : 2021

Identifying early indicators of secondary peritonitis in critically ill patients with cirrhosis

Antoine Vieillard-Baron
Olivier Lesieur
  • Fonction : Auteur
Nicolas Pichon
  • Fonction : Auteur
Cedric Bruel
Damien Roux

Résumé

Ascitic fluid infection (AFI) is a life-threatening complication of cirrhosis. We aimed to identify early indicators of secondary peritonitis (SP), which requires emergency surgery, and to describe the outcomes of SP and spontaneous bacterial/fungal peritonitis (SBFP). Adults with cirrhosis and AFI admitted to 16 university or university-affiliated ICUs in France between 2002 and 2017 were studied retrospectively. Cases were identified by searching the hospital databases for relevant ICD-10 codes and hospital charts for AFI. Logistic multivariate regression was performed to identify factors associated with SP. Secondary outcomes were short-and long-term mortality and survivors' functional outcomes. Of 178 included patients (137 men and 41 women; mean age, 58 ± 11 years), 21 (11.8%) had SP, confirmed by surgery in 16 cases and by abdominal computed tomography in 5 cases. Time to diagnosis exceeded 24 h in 7/21 patients with SP. By multivariate analysis, factors independently associated with SP were ascitic leukocyte count > 10,000/mm 3 (OR 3.70; 95%CI 1.38-9.85; P = 0.009) and absence of laboratory signs of decompensated cirrhosis (OR 4.53; 95%CI 1.30-15.68; P = 0.017). The 1-year mortality rates in patients with SBFP and SP were 81.0% and 77.5%, respectively (Logrank test, P = 0.92). Patients with SP vs. SBFP had no differences in 1-year functional outcomes. This multicenter retrospective study identified two indicators of SP as opposed to SBFP in patients with cirrhosis. Using these indicators may help to provide early surgical treatment.
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hal-03408884 , version 1 (29-10-2021)

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Carole Ruault, Nathalie Zappella, Julien Labreuche, Pierrick Cronier, Baptiste Claude, et al.. Identifying early indicators of secondary peritonitis in critically ill patients with cirrhosis. Scientific Reports, 2021, 11 (1), ⟨10.1038/s41598-021-00629-4⟩. ⟨hal-03408884⟩
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