HDL functionality in type 1 and type 2 diabetes - Sorbonne Université Accéder directement au contenu
Article Dans Une Revue Current Opinion in Endocrinology, Diabetes and Obesity Année : 2022

HDL functionality in type 1 and type 2 diabetes

Résumé

Purpose of review To critically appraise new insights into HDL structure and function in type 1 diabetes (T1DM) and type 2 diabetes (T2DM). Recent findings In young T1DM patients with early renal impairment and a high inflammatory score, both HDL antioxidative activity and endothelial vasodilatory function were impaired, revealing a critical link between HDL dysfunction, subclinical vascular damage, systemic inflammation and end organ damage. HDL may inhibit development of T2DM by attenuating endoplasmic reticulum (ER) stress and apoptotic loss of pancreatic β-cells, an effect due in part to ABC transporter-mediated efflux of specific oxysterols with downstream activation of the hedghehog signalling receptor, Smoothened. The apoM-sphingosine-1-phosphate complex is critical to HDL antidiabetic activity, encompassing protection against insulin resistance, promotion of insulin secretion, enhanced β-cell survival and inhibition of hepatic glucose production. Structure-function studies of HDL in hyperglycemic, dyslipidemic T2DM patients revealed both gain and loss of lipidomic and proteomic components. Such changes attenuated both the optimal protective effects of HDL on mitochondrial function and its capacity to inhibit endothelial cell apoptosis. Distinct structural components associated with individual HDL functions. Summary Extensive evidence indicates that both the proteome and lipidome of HDL are altered in T1DM and T2DM, with impairment of multiple functions.
Fichier principal
Vignette du fichier
HDL_functionality_in_type_1_and_type_2_diabetes_.99148.pdf (1.36 Mo) Télécharger le fichier
Origine : Publication financée par une institution

Dates et versions

hal-03511999 , version 1 (05-01-2022)

Identifiants

Citer

M. John John Chapman. HDL functionality in type 1 and type 2 diabetes. Current Opinion in Endocrinology, Diabetes and Obesity, 2022, ⟨10.1097/MED.0000000000000705⟩. ⟨hal-03511999⟩
37 Consultations
48 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More