Article Dans Une Revue OncoImmunology Année : 2022

Immunostimulatory effects of vitamin B5 improve anticancer immunotherapy

Résumé

Vitamin B5 (panthotenic acid), the precursor of coenzyme A (CoA), is contained in most food items and is produced by the intestinal microbiota. A recent study published in Cell Metabolism reports that vitamin B5 and CoA favor the differentiation of CD8 + cytotoxic T cells into interleukin-22 (IL-22)-producing Tc22 cells, likely through fueling mitochondrial metabolism. Importantly, in a small cohort of melanoma patients, the plasma levels of vitamin B5 positively correlate with responses to PD-1-targeted immunotherapy. Moreover, in mice, supplementation with vitamin B5 increases the efficacy of PD-L1-targeted cancer immunotherapy, and in vitro culture of T cells with CoA enhances their antitumor activity upon adoptive transfer into mice. These finding suggest that vitamin B5 is yet another B vitamin that stimulates anticancer immunosurveillance.

Domaines

Immunologie
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Dates et versions

hal-03551228 , version 1 (01-02-2022)

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Melanie Bourgin, Oliver Kepp, Guido Kroemer. Immunostimulatory effects of vitamin B5 improve anticancer immunotherapy. OncoImmunology, 2022, 11 (1), ⟨10.1080/2162402x.2022.2031500⟩. ⟨hal-03551228⟩
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