Article Dans Une Revue International Journal of Molecular Sciences Année : 2022

Enteroendocrine System and Gut Barrier in Metabolic Disorders

Résumé

With the continuous rise in the worldwide prevalence of obesity and type 2 diabetes, developing therapies regulating body weight and glycemia has become a matter of great concern. Among the current treatments, evidence now shows that the use of intestinal hormone analogs (e.g., GLP1 analogs and others) helps to control glycemia and reduces body weight. Indeed, intestinal endocrine cells produce a large variety of hormones regulating metabolism, including appetite, digestion, and glucose homeostasis. Herein, we discuss how the enteroendocrine system is affected by local environmental and metabolic signals. These signals include those arising from unbalanced diet, gut microbiota, and the host metabolic organs and their complex cross-talk with the intestinal barrier integrity.
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Dates et versions

hal-03651483 , version 1 (25-04-2022)

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Céline Osinski, Dounia Moret, Karine Clément, Patricia Serradas, Agnès Ribeiro. Enteroendocrine System and Gut Barrier in Metabolic Disorders. International Journal of Molecular Sciences, 2022, 23 (7), pp.3732. ⟨10.3390/ijms23073732⟩. ⟨hal-03651483⟩
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