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Journal Articles Journal of Cannabis Research Year : 2022

Cannabis use as a factor of lower corpulence in hepatitis C-infected patients: results from the ANRS CO22 Hepather cohort

Tangui Barré (1) , Fabrice Carrat (2, 3) , Clémence Ramier (1) , Hélène Fontaine (4) , Vincent Di Beo (1) , Morgane Bureau (1) , Céline Dorival (2) , Dominique Larrey (5) , Elisabeth Delarocque-Astagneau (6, 7) , Philippe Mathurin (8, 9) , Fabienne Marcellin (1) , Ventzislava Petrov-Sanchez (10) , Carole Cagnot (10) , Patrizia Carrieri (1) , Stanislas Pol (4) , Camelia Protopopescu (1) , Laurent Alric , Chloe Pomes , Fabien Zoulim , Marianne Maynard , Roxane Bai , Lucie Hucault , François Bailly , François Raffi , Eric Billaud , David Boutoille , Maeva Lefebvre , Elisabeth André-Garnier , Paul Cales , Isabelle Hubert , Adrien Lannes , Françoise Lunel , Jérôme Boursier , Tarik Asselah , Nathalie Boyer , Nathalie Giuily , Corinne Castelnau , Giovanna Scoazec , Emilie Rousseaud , Anaïs Vallet-Pichard , Philippe Sogni , Victor de Ledinghen , Juliette Foucher , Jean-Baptiste Hiriart , Jancell M’bouyou , Marie Irlès-Depé , Marc Bourlière , Si Nafa Si Ahmed , Valérie Oules , Albert Tran , Rodolphe Anty , Eve Gelsi , Régine Truchi , Dominique Thabut , Saloua Hammeche , Joseph Moussali , Xavier Causse , Barbara de Dieuleveult , Brahim Ouarani , Damien Labarrière , Nathalie Ganne , Véronique Grando-Lemaire , Pierre Nahon , Séverine Brulé , Betul Ulker , Dominique Guyader , Caroline Jezequel , Audrey Brener , Anne Laligant , Aline Rabot , Isabelle Renard , François Habersetzer , Thomas Baumert , Michel Doffoel , Catherine Mutter , Pauline Simo-Noumbissie , Esma Razi , Jean-Pierre Bronowicki , Hélène Barraud , Mouni Bensenane , Abdelbasset Nani , Sarah Hassani-Nani , Marie-Albertine Bernard , Georges-Philippe Pageaux , Magda Meszaros , Sophie Metivier , Christophe Bureau , Thibault Morales , Jean Marie Peron , Marie Angèle Robic , Thomas Decaens , Marine Faure , Bruno Froissart , Marie-Noelle Hilleret , Jean-Pierre Zarski , Ghassan Riachi , Odile Goria , Fatima Paris , Hélène Montialoux , Vincent Leroy , Giuliana Amaddeo , Anne Varaut , Mélanie Simoes , Rachida Amzal , Olivier Chazouillières , Tony Andreani , Bénédicte Angoulevant , Azeline Chevance , Lawrence Serfaty , Didier Samuel , Teresa Antonini , Audrey Coilly , Jean-Charles Duclos-Vallée , Mariagrazia Tateo , Armand Abergel , Maud Reymond , Chanteranne Brigitte , Buchard Benjamin , Léon Muti , Claire Geist , Guillaume Conroy , Raphaëlle Riffault , Isabelle Rosa , Camille Barrault , Laurent Costes , Hervé Hagège , Véronique Loustaud-Ratti , Paul Carrier , Maryline Debette-Gratien , Guillaume Lassailly , Elise Lemaitre , Valérie Canva , Sébastien Dharancy , Alexandre Louvet , Anne Minello , Marianne Latournerie , Marc Bardou , Thomas Mouillot , Louis D’alteroche , Didier Barbereau , Charlotte Nicolas , Laure Elkrief , Anaïs Jaillais , Jérôme Gournay , Caroline Chevalier , Isabelle Archambeaud , Sarah Habes , Isabelle Portal , Moana Gelu-Simeon , Eric Saillard , Marie-Josée Lafrance , Lucie Catherine , Frederic Chau , Isabelle Goderel , Clovis Lusivika-Nzinga , Marc-Antoine Bellance , Jonathan Bellet , Priscilla Monfalet , Jessica Chane-Teng , Sephora Bijaoui , Grégory Pannetier , François Téoulé , Jérôme Nicol , Florian Sebal , Rafika Bekhti , Anaïs Boston , Laura Nailler , Guillaume Le Meut , Alpha Diallo , Marc Bourlière , Jérôme Boursier , Victor de Ledinghen , Slim Fourati , Chantal Housset , Pierre Nahon , Georges-Philippe Pageaux , Mathias Bruyand , Linda Wittkop , Fabien Zoulim , Jessica Zucman-Rossi , Marianne L’hennaff , Michèle Sizorn
Laurent Alric
  • Function : Author
Chloe Pomes
  • Function : Author
Fabien Zoulim
Marianne Maynard
  • Function : Author
Roxane Bai
  • Function : Author
Lucie Hucault
  • Function : Author
François Bailly
  • Function : Author
François Raffi
  • Function : Author
Eric Billaud
  • Function : Author
David Boutoille
  • Function : Author
Maeva Lefebvre
  • Function : Author
Elisabeth André-Garnier
  • Function : Author
Paul Cales
Isabelle Hubert
  • Function : Author
Adrien Lannes
  • Function : Author
Françoise Lunel
  • Function : Author
Jérôme Boursier
  • Function : Author
Tarik Asselah
  • Function : Author
Nathalie Boyer
  • Function : Author
Nathalie Giuily
  • Function : Author
Corinne Castelnau
  • Function : Author
Giovanna Scoazec
  • Function : Author
Emilie Rousseaud
  • Function : Author
Anaïs Vallet-Pichard
  • Function : Author
Philippe Sogni
  • Function : Author
Victor de Ledinghen
  • Function : Author
Juliette Foucher
  • Function : Author
Jean-Baptiste Hiriart
  • Function : Author
Jancell M’bouyou
  • Function : Author
Marie Irlès-Depé
  • Function : Author
Marc Bourlière
  • Function : Author
Si Nafa Si Ahmed
  • Function : Author
Valérie Oules
  • Function : Author
Albert Tran
  • Function : Author
Rodolphe Anty
  • Function : Author
Eve Gelsi
  • Function : Author
Régine Truchi
  • Function : Author
Dominique Thabut
  • Function : Author
Saloua Hammeche
  • Function : Author
Joseph Moussali
  • Function : Author
Xavier Causse
  • Function : Author
Barbara de Dieuleveult
  • Function : Author
Brahim Ouarani
  • Function : Author
Damien Labarrière
  • Function : Author
Nathalie Ganne
  • Function : Author
Véronique Grando-Lemaire
  • Function : Author
Pierre Nahon
  • Function : Author
Séverine Brulé
  • Function : Author
Betul Ulker
  • Function : Author
Dominique Guyader
  • Function : Author
Caroline Jezequel
  • Function : Author
Audrey Brener
  • Function : Author
Anne Laligant
  • Function : Author
Aline Rabot
  • Function : Author
Isabelle Renard
  • Function : Author
François Habersetzer
  • Function : Author
Thomas Baumert
  • Function : Author
Michel Doffoel
  • Function : Author
Catherine Mutter
  • Function : Author
Pauline Simo-Noumbissie
  • Function : Author
Esma Razi
  • Function : Author
Jean-Pierre Bronowicki
  • Function : Author
Hélène Barraud
  • Function : Author
Mouni Bensenane
  • Function : Author
Abdelbasset Nani
  • Function : Author
Sarah Hassani-Nani
  • Function : Author
Marie-Albertine Bernard
  • Function : Author
Georges-Philippe Pageaux
  • Function : Author
Magda Meszaros
  • Function : Author
Sophie Metivier
  • Function : Author
Christophe Bureau
  • Function : Author
Thibault Morales
  • Function : Author
Jean Marie Peron
  • Function : Author
Marie Angèle Robic
  • Function : Author
Thomas Decaens
  • Function : Author
Marine Faure
  • Function : Author
Bruno Froissart
  • Function : Author
Marie-Noelle Hilleret
  • Function : Author
Jean-Pierre Zarski
  • Function : Author
Ghassan Riachi
  • Function : Author
Odile Goria
  • Function : Author
Fatima Paris
  • Function : Author
Hélène Montialoux
  • Function : Author
Vincent Leroy
  • Function : Author
Giuliana Amaddeo
  • Function : Author
Anne Varaut
  • Function : Author
Mélanie Simoes
  • Function : Author
Rachida Amzal
  • Function : Author
Olivier Chazouillières
  • Function : Author
Tony Andreani
  • Function : Author
Bénédicte Angoulevant
  • Function : Author
Azeline Chevance
  • Function : Author
Lawrence Serfaty
  • Function : Author
Didier Samuel
  • Function : Author
Teresa Antonini
  • Function : Author
Audrey Coilly
  • Function : Author
Jean-Charles Duclos-Vallée
  • Function : Author
Mariagrazia Tateo
  • Function : Author
Armand Abergel
Maud Reymond
  • Function : Author
Chanteranne Brigitte
  • Function : Author
Buchard Benjamin
  • Function : Author
Léon Muti
  • Function : Author
Claire Geist
  • Function : Author
Guillaume Conroy
  • Function : Author
Raphaëlle Riffault
  • Function : Author
Isabelle Rosa
  • Function : Author
Camille Barrault
  • Function : Author
Laurent Costes
  • Function : Author
Hervé Hagège
  • Function : Author
Véronique Loustaud-Ratti
  • Function : Author
Paul Carrier
  • Function : Author
Maryline Debette-Gratien
  • Function : Author
Guillaume Lassailly
  • Function : Author
Elise Lemaitre
  • Function : Author
Valérie Canva
  • Function : Author
Sébastien Dharancy
  • Function : Author
Alexandre Louvet
  • Function : Author
Anne Minello
  • Function : Author
Marianne Latournerie
  • Function : Author
Marc Bardou
  • Function : Author
Thomas Mouillot
  • Function : Author
Louis D’alteroche
  • Function : Author
Didier Barbereau
  • Function : Author
Charlotte Nicolas
  • Function : Author
Laure Elkrief
  • Function : Author
Anaïs Jaillais
  • Function : Author
Jérôme Gournay
  • Function : Author
Caroline Chevalier
  • Function : Author
Isabelle Archambeaud
  • Function : Author
Sarah Habes
  • Function : Author
Isabelle Portal
  • Function : Author
Moana Gelu-Simeon
  • Function : Author
Eric Saillard
  • Function : Author
Marie-Josée Lafrance
  • Function : Author
Lucie Catherine
  • Function : Author
Frederic Chau
  • Function : Author
Isabelle Goderel
  • Function : Author
Clovis Lusivika-Nzinga
Marc-Antoine Bellance
  • Function : Author
Jonathan Bellet
  • Function : Author
Priscilla Monfalet
  • Function : Author
Jessica Chane-Teng
  • Function : Author
Sephora Bijaoui
  • Function : Author
Grégory Pannetier
  • Function : Author
François Téoulé
  • Function : Author
Jérôme Nicol
  • Function : Author
Florian Sebal
  • Function : Author
Rafika Bekhti
  • Function : Author
Anaïs Boston
  • Function : Author
Laura Nailler
  • Function : Author
Guillaume Le Meut
  • Function : Author
Alpha Diallo
  • Function : Author
Marc Bourlière
  • Function : Author
Jérôme Boursier
  • Function : Author
Victor de Ledinghen
  • Function : Author
Slim Fourati
  • Function : Author
Chantal Housset
  • Function : Author
Pierre Nahon
  • Function : Author
Georges-Philippe Pageaux
  • Function : Author
Mathias Bruyand
  • Function : Author
Linda Wittkop
  • Function : Author
Fabien Zoulim
  • Function : Author
Jessica Zucman-Rossi
  • Function : Author
Marianne L’hennaff
  • Function : Author
Michèle Sizorn
  • Function : Author

Abstract

Background: Patients with chronic hepatitis C virus (HCV) infection are at greater risk of developing metabolic disorders. Obesity is a major risk factor for these disorders, and therefore, managing body weight is crucial. Cannabis use, which is common in these patients, has been associated with lower corpulence in various populations. However, this relationship has not yet been studied in persons with chronic HCV infection. Methods: Using baseline data from the French ANRS CO22 Hepather cohort, we used binary logistic and multinomial logistic regression models to test for an inverse relationship between cannabis use (former/current) and (i) central obesity (i.e., large waist circumference) and (ii) overweight and obesity (i.e., elevated body mass index (BMI)) in patients from the cohort who had chronic HCV infection. We also tested for relationships between cannabis use and both waist circumference and BMI as continuous variables, using linear regression models. Results: Among the 6348 participants in the study population, 55% had central obesity, 13.7% had obesity according to their BMI, and 12.4% were current cannabis users. After multivariable adjustment, current cannabis use was associated with lower risk of central obesity (adjusted odds ratio, aOR [95% confidence interval, CI]: 0.45 [0.37-0.55]), BMI-based obesity (adjusted relative risk ratio (aRRR) [95% CI]: 0.27 [0.19-0.39]), and overweight (aRRR [95% CI]: 0.47 [0.38-0.59]). This was also true for former use, but to a lesser extent. Former and current cannabis use were inversely associated with waist circumference and BMI. Conclusions: We found that former and, to a greater extent, current cannabis use were consistently associated with smaller waist circumference, lower BMI, and lower risks of overweight, obesity, and central obesity in patients with chronic HCV infection. Longitudinal studies are needed to confirm these relationships and to assess the effect of cannabis use on corpulence and liver outcomes after HCV cure. Trial registration: ClinicalTrials.gov identifier: NCT01953458 .
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hal-03784790 , version 1 (23-09-2022)

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Tangui Barré, Fabrice Carrat, Clémence Ramier, Hélène Fontaine, Vincent Di Beo, et al.. Cannabis use as a factor of lower corpulence in hepatitis C-infected patients: results from the ANRS CO22 Hepather cohort. Journal of Cannabis Research, 2022, 4 (1), pp.31. ⟨10.1186/s42238-022-00138-9⟩. ⟨hal-03784790⟩
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