Linear Immunoglobulin a Bullous Dermatosis in Children - Sorbonne Université
Article Dans Une Revue Frontiers in pediatrics Année : 2022

Linear Immunoglobulin a Bullous Dermatosis in Children

Francesca Saretta
  • Fonction : Auteur
Lucia Liotti
  • Fonction : Auteur
Carla Mastrorilli
  • Fonction : Auteur
Luca Pecoraro
  • Fonction : Auteur
Lucia Caminiti
  • Fonction : Auteur

Résumé

Linear Immunoglobulin A Bullous Disease (LABD) is a rare dermatosis whose pathomechanisms are not yet completely understood. LABD has different features characterizing adults and children in terms of potential triggers, clinical manifestations, and prognosis. The aim of the present study is to review all neonatal and pediatric cases of LABD and summarize the major characteristics. Childhood LABD is mainly idiopathic with a benign prognosis. Neonatal cases are difficult to differentiate from infectious diseases and usually have a poor prognosis. Drugs are one of the possible triggers that can activate autoimmune responses through antigen mimicry and epitope spreading as well as different stimuli (e.g., infections, inflammatory diseases, trauma). The gold standard for the diagnosis is based on direct immunofluorescence. Prognosis is generally favorable but often depends on the prompt dermatological diagnosis, treatment and follow-up guaranteed by a multidisciplinary team, including pediatricians for this group of age.

Dates et versions

hal-03896070 , version 1 (13-12-2022)

Identifiants

Citer

Francesca Mori, Francesca Saretta, Lucia Liotti, Mattia Giovannini, Riccardo Castagnoli, et al.. Linear Immunoglobulin a Bullous Dermatosis in Children. Frontiers in pediatrics, 2022, 10, pp.937528. ⟨10.3389/fped.2022.937528⟩. ⟨hal-03896070⟩
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