Cumulative incidence of SARS-CoV-2 infection and associated risk factors among frontline health care workers in Paris: the SEROCOV cohort study - Sorbonne Université
Journal Articles Scientific Reports Year : 2022

Cumulative incidence of SARS-CoV-2 infection and associated risk factors among frontline health care workers in Paris: the SEROCOV cohort study

Michel Djibré
  • Function : Author
Rudy Bompard
  • Function : Author

Abstract

Abstract With the COVID-19 pandemic, documenting whether health care workers (HCWs) are at increased risk of SARS-CoV-2 contamination and identifying risk factors is of major concern. In this multicenter prospective cohort study, HCWs from frontline departments were included in March and April 2020 and followed for 3 months. SARS-CoV-2 serology was performed at month 0 (M0), M1, and M3 and RT-PCR in case of symptoms. The primary outcome was laboratory-confirmed SARS-CoV-2 infection at M3. Risk factors of laboratory-confirmed SARS-CoV-2 infection at M3 were identified by multivariate logistic regression. Among 1062 HCWs (median [interquartile range] age, 33 [28–42] years; 758 [71.4%] women; 321 [30.2%] physicians), the cumulative incidence of SARS-CoV-2 infection at M3 was 14.6% (95% confidence interval [CI] [12.5; 16.9]). Risk factors were the working department specialty, with increased risk for intensive care units (odds ratio 1.80, 95% CI [0.38; 8.58]), emergency departments (3.91 [0.83; 18.43]) and infectious diseases departments (4.22 [0.92; 18.28]); current smoking was associated with reduced risk (0.36 [0.21; 0.63]). Age, sex, professional category, number of years of experience in the job or department, and public transportation use were not significantly associated with laboratory-confirmed SARS-CoV-2 infection at M3. The rate of SARS-CoV-2 infection in frontline HCWs was 14.6% at the end of the first COVID-19 wave in Paris and occurred mainly early. The study argues for an origin of professional in addition to private life contamination and therefore including HCWs in the first-line vaccination target population. It also highlights that smokers were at lower risk. Trial registration The study has been registered on ClinicalTrials.gov: NCT04304690 first registered on 11/03/2020.
Fichier principal
Vignette du fichier
Hausfater_et_al-2022-Scientific_Reports.pdf (1.24 Mo) Télécharger le fichier
Figure 1 R1.pdf (119.3 Ko) Télécharger le fichier
Figure 3 R1.pdf (303.34 Ko) Télécharger le fichier
Table R1.pdf (225.08 Ko) Télécharger le fichier
manuscrit SEROCOV_final R1.pdf (137.28 Ko) Télécharger le fichier
supplementary materials 1.pdf (548.44 Ko) Télécharger le fichier
Origin Files produced by the author(s)
Origin Files produced by the author(s)
Origin Files produced by the author(s)

Dates and versions

hal-03920105 , version 1 (14-02-2023)

Identifiers

Cite

Pierre Hausfater, David Boutolleau, Karine Lacombe, Alexandra Beurton, Margaux Dumont, et al.. Cumulative incidence of SARS-CoV-2 infection and associated risk factors among frontline health care workers in Paris: the SEROCOV cohort study. Scientific Reports, 2022, 12 (1), pp.7211. ⟨10.1038/s41598-022-10945-y⟩. ⟨hal-03920105⟩
117 View
58 Download

Altmetric

Share

More