Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs neutralizing type I IFNs
Paul Bastard
(1, 2, 3)
,
Sara Vazquez
,
Jamin Liu
,
Matthew T Laurie
,
Chung Yu Wang
,
Adrian Gervais
,
Tom Le Voyer
(4)
,
Lucy Bizien
(1)
,
Colin Zamecnik
,
Quentin Philippot
(2)
,
Jérémie Rosain
(5, 6)
,
Emilie Catherinot
(7)
,
Andrew Willmore
,
Anthea M Mitchell
,
Rebecca Bair
,
Pierre Garçon
(8)
,
Heather Kenney
,
Arnaud Fekkar
(9)
,
Maria Salagianni
,
Garyphallia Poulakou
(10)
,
Eleni Siouti
,
Sabina Sahanic
(11)
,
Ivan Tancevski
(11)
,
Günter Weiss
(11)
,
Laurenz Nagl
,
Jérémy Manry
(12, 13)
,
Sotirija Duvlis
(14)
,
Daniel Arroyo-Sánchez
,
Estela Paz Artal
,
Luis Rubio
,
Cristiano Perani
,
Michela Bezzi
,
Alessandra Sottini
,
Virginia Quaresima
,
Lucie Roussel
,
Donald C Vinh
,
Luis Felipe Reyes
,
Margaux Garzaro
,
Nevin Hatipoglu
,
David Boutboul
,
Yacine Tandjaoui-Lambiotte
,
Alessandro Borghesi
,
Anna Aliberti
,
Irene Cassaniti
,
Fabienne Venet
,
Guillaume Monneret
,
Rabih Halwani
,
Narjes Saheb Sharif-Askari
,
Jeffrey Danielson
,
Sonia Burrel
,
Caroline Morbieu
,
Yurii Stepanovskyy
,
Anastasia Bondarenko
,
Alla Volokha
,
Oksana Boyarchuk
,
Alenka Gagro
,
Mathilde Neuville
,
Bénédicte Neven
,
Sevgi Keles
,
Romain Hernu
,
Antonin Bal
,
Antonio Novelli
,
Giuseppe Novelli
,
Kahina Saker
,
Oana Ailioaie
,
Arnau Antolí
,
Eric Jeziorski
(15, 16)
,
Gemma Rocamora-Blanch
,
Carla Teixeira
,
Clarisse Delaunay
,
Marine Lhuillier
,
Paul Le Turnier
,
Yu Zhang
,
Matthieu Mahevas
,
Qiang Pan-Hammarström
,
Hassan Abolhassani
,
Thierry Bompoil
,
Karim Dorgham
,
Guy Gorochov
,
Cédric Laouenan
,
Carlos Rodríguez-Gallego
,
Lisa F P Ng
,
Laurent Renia
,
Aurora Pujol
,
Alexandre Belot
,
François Raffi
,
Luis M Allende
,
Javier Martinez-Picado
,
Tayfun Ozcelik
,
Sevgi Keles
,
Luisa Imberti
,
Luigi D Notarangelo
,
Jesus Troya
,
Xavier Solanich
,
Shen-Ying Zhang
,
Anne Puel
,
Michael R Wilson
,
Sophie Trouillet-Assant
,
Laurent Abel
,
Emmanuelle Jouanguy
,
Chun Jimmie Ye
,
Aurélie Cobat
,
Leslie M Thompson
,
Evangelos Andreakos
,
Qian Zhang
,
Mark S Anderson
,
Jean-Laurent Casanova
(17)
,
Joseph L Derisi
,
Laurent Abel
,
Cristian Achille
,
Alessandro Aiuti
,
Saleh Al-Muhsen
,
Fahd Al-Mulla
,
Mark S Anderson
,
Evangelos Andreakos
,
Micol Angelini
,
Andrés A Arias
,
Gokhan Aytekin
,
Fausto Baldanti
,
Hagit Baris Feldman
,
Alexandre Belot
,
Federica Bergami
,
Catherine M Biggs
,
Dusan Bogunovic
,
Alexandre Bolze
,
Anastasiia Bondarenko
,
Ahmed A Bousfiha
,
Petter Brodin
,
Yenan Bryceson
,
Carlos D Bustamante
,
Manish J Butte
,
Giorgio Casari
,
John Christodoulou
,
Antonio Condino-Neto
,
Stefan N Constantinescu
,
Francesca Conti
,
Megan A Cooper
,
Clifton L Dalgard
,
Murkesh Desai
,
Beth A Drolet
,
Jamila El Baghdadi
,
Recai Ergun
,
Dilek Ergun
,
Sara Espinosa-Padilla
,
Jacques Fellay
,
Carlos Flores
,
José Luis Franco
,
Antoine Froidure
,
Stefano Ghirardello
,
Peter K Gregersen
,
Bodo Grimbacher
,
Filomeen Haerynck
,
David Hagin
,
Rabih Halwani
,
Lennart Hammarström
,
James R Heath
,
Sarah E Henrickson
,
Elena W Y Hsieh
,
Eystein Husebye
,
Kohsuke Imai
,
Yuval Itan
,
Erich D Jarvis
,
Fikret Kanat
,
Timokratis Karamitros
,
Kai Kisand
,
Vasyl Kopcha
,
Mykhaylo Korda
,
Cheng-Lung Ku
,
Yu-Lung Lau
,
Yun Ling
,
Carrie L Lucas
,
Tom Maniatis
,
Davood Mansouri
,
László Maródi
,
Isabelle Meyts
,
Joshua D Milner
,
Kristina Mironska
,
Trine H Mogensen
,
Francesco Mojoli
,
Francisco Morandeira
,
Tomohiro Morio
,
Lisa F P Ng
,
Luigi D Notarangelo
,
Antonio Novelli
,
Giuseppe Novelli
,
Cliona O'Farrelly
,
Satoshi Okada
,
Keisuke Okamoto
,
Tayfun Ozcelik
,
Michele Pagani
,
Qiang Pan-Hammarström
,
Jean W Pape
,
Rebeca Perez de Diego
,
David S Perlin
,
Graziano Pesole
,
Andrea Pession
,
Antonio Piralla
,
Anna M Planas
,
Carolina Prando
,
Aurora Pujol
,
Lluis Quintana-Murci
(17)
,
Sathishkumar Ramaswamy
,
Laurent Renia
,
Igor Resnick
,
Raúl Rigo-Bonnin
,
Carlos Rodríguez-Gallego
,
Vanessa Sancho-Shimizu
,
Anna Sediva
,
Mikko R J Seppänen
,
Mohammed Shahrooei
,
Anna Shcherbina
,
Ondrej Slaby
,
Andrew L Snow
,
Pere Soler-Palacín
,
András N Spaan
,
Ivan Tancevski
,
Stuart G Tangye
,
Ahmad Abou Tayoun
,
Baykal Tulek
,
Stuart E Turvey
,
K M Furkan Uddin
,
Mohammed Uddin
,
Bénédicte Clément
,
Yumiko Abe-Jones
,
Saurabh Asthana
,
Sharvari Bhide
,
Carolyn S Calfee
,
Sidney A Carrillo
,
Suzanna Chak
,
Zachary Collins
,
David J Erle
,
Gabriela K Fragiadakis
,
Rajani Ghale
,
Carolyn M Hendrickson
,
Alejandra Jauregui
,
Kirsten N Kangelaris
,
Matthew F Krummel
,
Charles R Langelier
,
Tasha Lea
,
Deanna Lee
,
Aleksandra Leligdowicz
,
Carolyn Leroux
,
Raphael Lota
,
Michael Matthay
,
Viet Nguyen
,
Ravi Patel
,
Logan Pierce
,
Priya Prasad
,
Arjun Arkal Rao
,
Ahmad Rashid
,
Nicklaus Rodriguez
,
Bushra Samad
,
Cole Shaw
,
Austin Sigman
,
Kevin Tang
,
Luz Torres Altamirano
,
Alyssa Ward
,
Andrew Willmore
,
Michael R Wilson
,
Prescott G Woodruff
,
Laurent Abel
,
Clotilde Allavena
,
Claire Andrejak
,
François Angoulvant
,
Cecile Azoulay
,
Delphine Bachelet
,
Marie Bartoli
,
Romain Basmaci
,
Sylvie Behilill
,
Marine Beluze
,
Nicolas Benech
,
Dehbia Benkerrou
,
Krishna Bhavsar
,
Laurent Bitker
,
Lila Bouadma
,
Maude Bouscambert
,
Pauline Caraux Paz
,
Minerva Cervantes-Gonzalez
,
Anissa Chair
,
Catherine Chirouze
,
Alexandra Coelho
,
Hugues Cordel
,
Camille Couffignal
,
Sandrine Couffin-Cadiergues
,
Eric D’ortenzio
,
Etienne de Montmollin
,
Alexa Debard
,
Marie-Pierre Debray
,
Dominique Deplanque
,
Diane Descamps
,
Mathilde Desvallée
,
Alpha Diallo
,
Jean-Luc Diehl
,
Alphonsine Diouf
,
Céline Dorival
,
François Dubos
,
Xavier Duval
,
Philippine Eloy
,
Vincent Enouf
,
Olivier Epaulard
,
Hélène Esperou
,
Marina Esposito-Farese
,
Manuel Etienne
,
Denis Garot
,
Nathalie Gault
,
Alexandre Gaymard
,
Jade Ghosn
,
Tristan Gigante
,
Morgane Gilg
,
François Goehringer
,
Jérémie Guedj
,
Alexandre Hoctin
,
Isabelle Hoffmann
,
Ikram Houas
,
Jean-Sébastien Hulot
,
Salma Jaafoura
,
Ouifiya Kafif
,
Florentia Kaguelidou
,
Sabrina Kali
,
Younes Kerroumi
,
Antoine Khalil
,
Coralie Khan
,
Antoine Kimmoun
,
Fabrice Laine
,
Cédric Laouénan
,
Samira Laribi
,
Minh Le
,
Cyril Le Bris
,
Sylvie Le Gac
,
Quentin Le Hingrat
,
Soizic Le Mestre
,
Hervé Le Nagard
,
Adrien Lemaignen
,
Véronique Lemee
,
François-Xavier Lescure
,
Sophie Letrou
,
Yves Levy
,
Bruno Lina
,
Guillaume Lingas
,
Jean Christophe Lucet
,
Moïse Machado
,
Denis Malvy
,
Marina Mambert
,
Aldric Manuel
,
France Mentré
,
Amina Meziane
,
Hugo Mouquet
,
Jimmy Mullaert
,
Nadège Neant
,
Duc Nguyen
,
Marion Noret
,
Aurélie Papadopoulos
,
Christelle Paul
,
Nathan Peiffer-Smadja
,
Vincent Peigne
,
Ventzislava Petrov-Sanchez
,
Gilles Peytavin
,
Huong Pham
,
Olivier Picone
,
Valentine Piquard
,
Julien Poissy
,
Oriane Puéchal
,
Manuel Rosa-Calatrava
,
Bénédicte Rossignol
,
Patrick Rossignol
,
Carine Roy
,
Marion Schneider
,
Richa Su
,
Coralie Tardivon
,
Marie-Capucine Tellier
,
François Téoulé
,
Olivier Terrier
,
Jean-François Timsit
,
Christelle Tual
,
Sarah Tubiana
,
Sylvie van der Werf
,
Noémie Vanel
,
Aurélie Veislinger
,
Benoit Visseaux
,
Aurélie Wiedemann
,
Yazdan Yazdanpanah
1
Hôpital Necker - Enfants Malades [AP-HP]
2 Equipe Inserm U1163 - Human genetics of infectious diseases : Mendelian predisposition
3 Rockefeller University [New York]
4 Imagine - U1163 - Imagine - Institut des maladies génétiques (IHU)
5 IMAGINE - U1163 - Imagine - Institut des maladies génétiques
6 Center for the Study of Primary Immunodeficiencies [Paris]
7 Hôpital Foch [Suresnes]
8 GHEF - Grand Hôpital de l'Est Francilien
9 CHU Pitié-Salpêtrière [AP-HP]
10 4th Department of Internal Medicine
11 IMU - Innsbruck Medical University = Medizinische Universität Innsbruck
12 Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163
13 Imagine Institute
14 UGD - Goce Delchev University
15 PCCEI - Pathogenesis and Control of Chronic and Emerging Infections
16 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
17 Génétique Evolutive Humaine - Human Evolutionary Genetics
2 Equipe Inserm U1163 - Human genetics of infectious diseases : Mendelian predisposition
3 Rockefeller University [New York]
4 Imagine - U1163 - Imagine - Institut des maladies génétiques (IHU)
5 IMAGINE - U1163 - Imagine - Institut des maladies génétiques
6 Center for the Study of Primary Immunodeficiencies [Paris]
7 Hôpital Foch [Suresnes]
8 GHEF - Grand Hôpital de l'Est Francilien
9 CHU Pitié-Salpêtrière [AP-HP]
10 4th Department of Internal Medicine
11 IMU - Innsbruck Medical University = Medizinische Universität Innsbruck
12 Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163
13 Imagine Institute
14 UGD - Goce Delchev University
15 PCCEI - Pathogenesis and Control of Chronic and Emerging Infections
16 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
17 Génétique Evolutive Humaine - Human Evolutionary Genetics
Sara Vazquez
- Function : Author
Jamin Liu
- Function : Author
Matthew T Laurie
- Function : Author
Chung Yu Wang
- Function : Author
Adrian Gervais
- Function : Author
Colin Zamecnik
- Function : Author
Andrew Willmore
- Function : Author
Anthea M Mitchell
- Function : Author
Rebecca Bair
- Function : Author
Heather Kenney
- Function : Author
Maria Salagianni
- Function : Author
Eleni Siouti
- Function : Author
Laurenz Nagl
- Function : Author
Daniel Arroyo-Sánchez
- Function : Author
Estela Paz Artal
- Function : Author
Luis Rubio
- Function : Author
Cristiano Perani
- Function : Author
Michela Bezzi
- Function : Author
Alessandra Sottini
- Function : Author
Virginia Quaresima
- Function : Author
Lucie Roussel
- Function : Author
Donald C Vinh
- Function : Author
Luis Felipe Reyes
- Function : Author
Margaux Garzaro
- Function : Author
Nevin Hatipoglu
- Function : Author
David Boutboul
- Function : Author
Yacine Tandjaoui-Lambiotte
- Function : Author
Alessandro Borghesi
- Function : Author
Anna Aliberti
- Function : Author
Irene Cassaniti
- Function : Author
Fabienne Venet
- Function : Author
- PersonId : 793063
- ORCID : 0000-0003-0462-4235
- IdRef : 085511005
Guillaume Monneret
- Function : Author
- PersonId : 760513
- ORCID : 0000-0002-9961-5739
- IdRef : 080085679
Rabih Halwani
- Function : Author
Narjes Saheb Sharif-Askari
- Function : Author
Jeffrey Danielson
- Function : Author
Sonia Burrel
- Function : Author
Caroline Morbieu
- Function : Author
Yurii Stepanovskyy
- Function : Author
Anastasia Bondarenko
- Function : Author
Alla Volokha
- Function : Author
Oksana Boyarchuk
- Function : Author
Alenka Gagro
- Function : Author
Mathilde Neuville
- Function : Author
- PersonId : 1179766
- ORCID : 0000-0002-1774-6509
- IdRef : 159515378
Bénédicte Neven
- Function : Author
Sevgi Keles
- Function : Author
Romain Hernu
- Function : Author
Antonin Bal
- Function : Author
- PersonId : 791462
- ORCID : 0000-0002-0261-2495
Antonio Novelli
- Function : Author
Giuseppe Novelli
- Function : Author
Kahina Saker
- Function : Author
Oana Ailioaie
- Function : Author
Arnau Antolí
- Function : Author
Eric Jeziorski
- Function : Author
- PersonId : 1166461
- ORCID : 0000-0003-0318-3044
Gemma Rocamora-Blanch
- Function : Author
Carla Teixeira
- Function : Author
Clarisse Delaunay
- Function : Author
Marine Lhuillier
- Function : Author
Paul Le Turnier
- Function : Author
Yu Zhang
- Function : Author
Matthieu Mahevas
- Function : Author
Qiang Pan-Hammarström
- Function : Author
Hassan Abolhassani
- Function : Author
Thierry Bompoil
- Function : Author
Karim Dorgham
- Function : Author
Guy Gorochov
- Function : Author
Cédric Laouenan
- Function : Author
Carlos Rodríguez-Gallego
- Function : Author
Lisa F P Ng
- Function : Author
Laurent Renia
- Function : Author
Aurora Pujol
- Function : Author
Alexandre Belot
- Function : Author
- PersonId : 949521
- ORCID : 0000-0003-4902-5332
- IdRef : 115823824
François Raffi
- Function : Author
Luis M Allende
- Function : Author
Javier Martinez-Picado
- Function : Author
Tayfun Ozcelik
- Function : Author
Sevgi Keles
- Function : Author
Luisa Imberti
- Function : Author
Luigi D Notarangelo
- Function : Author
Jesus Troya
- Function : Author
Xavier Solanich
- Function : Author
Shen-Ying Zhang
- Function : Author
Anne Puel
- Function : Author
Michael R Wilson
- Function : Author
Sophie Trouillet-Assant
- Function : Author
- PersonId : 777652
- ORCID : 0000-0001-6439-4705
Laurent Abel
- Function : Author
Emmanuelle Jouanguy
- Function : Author
Chun Jimmie Ye
- Function : Author
Aurélie Cobat
- Function : Author
Leslie M Thompson
- Function : Author
Evangelos Andreakos
- Function : Author
Qian Zhang
- Function : Author
Mark S Anderson
- Function : Author
Joseph L Derisi
- Function : Author
Laurent Abel
- Function : Author
Cristian Achille
- Function : Author
Alessandro Aiuti
- Function : Author
Saleh Al-Muhsen
- Function : Author
Fahd Al-Mulla
- Function : Author
Mark S Anderson
- Function : Author
Evangelos Andreakos
- Function : Author
Micol Angelini
- Function : Author
Andrés A Arias
- Function : Author
Gokhan Aytekin
- Function : Author
Fausto Baldanti
- Function : Author
Hagit Baris Feldman
- Function : Author
Alexandre Belot
- Function : Author
Federica Bergami
- Function : Author
Catherine M Biggs
- Function : Author
Dusan Bogunovic
- Function : Author
Alexandre Bolze
- Function : Author
Anastasiia Bondarenko
- Function : Author
Ahmed A Bousfiha
- Function : Author
Petter Brodin
- Function : Author
Yenan Bryceson
- Function : Author
Carlos D Bustamante
- Function : Author
Manish J Butte
- Function : Author
Giorgio Casari
- Function : Author
John Christodoulou
- Function : Author
Antonio Condino-Neto
- Function : Author
Stefan N Constantinescu
- Function : Author
Francesca Conti
- Function : Author
Megan A Cooper
- Function : Author
Clifton L Dalgard
- Function : Author
Murkesh Desai
- Function : Author
Beth A Drolet
- Function : Author
Jamila El Baghdadi
- Function : Author
Recai Ergun
- Function : Author
Dilek Ergun
- Function : Author
Sara Espinosa-Padilla
- Function : Author
Jacques Fellay
- Function : Author
Carlos Flores
- Function : Author
José Luis Franco
- Function : Author
Antoine Froidure
- Function : Author
Stefano Ghirardello
- Function : Author
Peter K Gregersen
- Function : Author
Bodo Grimbacher
- Function : Author
Filomeen Haerynck
- Function : Author
David Hagin
- Function : Author
Rabih Halwani
- Function : Author
Lennart Hammarström
- Function : Author
James R Heath
- Function : Author
Sarah E Henrickson
- Function : Author
Elena W Y Hsieh
- Function : Author
Eystein Husebye
- Function : Author
Kohsuke Imai
- Function : Author
Yuval Itan
- Function : Author
Erich D Jarvis
- Function : Author
Fikret Kanat
- Function : Author
Timokratis Karamitros
- Function : Author
Kai Kisand
- Function : Author
Vasyl Kopcha
- Function : Author
Mykhaylo Korda
- Function : Author
Cheng-Lung Ku
- Function : Author
Yu-Lung Lau
- Function : Author
Yun Ling
- Function : Author
Carrie L Lucas
- Function : Author
Tom Maniatis
- Function : Author
Davood Mansouri
- Function : Author
László Maródi
- Function : Author
Isabelle Meyts
- Function : Author
Joshua D Milner
- Function : Author
Kristina Mironska
- Function : Author
Trine H Mogensen
- Function : Author
Francesco Mojoli
- Function : Author
Francisco Morandeira
- Function : Author
Tomohiro Morio
- Function : Author
Lisa F P Ng
- Function : Author
Luigi D Notarangelo
- Function : Author
Antonio Novelli
- Function : Author
Giuseppe Novelli
- Function : Author
Cliona O'Farrelly
- Function : Author
Satoshi Okada
- Function : Author
Keisuke Okamoto
- Function : Author
Tayfun Ozcelik
- Function : Author
Michele Pagani
- Function : Author
Qiang Pan-Hammarström
- Function : Author
Jean W Pape
- Function : Author
Rebeca Perez de Diego
- Function : Author
David S Perlin
- Function : Author
Graziano Pesole
- Function : Author
Andrea Pession
- Function : Author
Antonio Piralla
- Function : Author
Anna M Planas
- Function : Author
Carolina Prando
- Function : Author
Aurora Pujol
- Function : Author
Lluis Quintana-Murci
- Function : Author
- PersonId : 754080
- IdHAL : lluis-quintana-murci
- ORCID : 0000-0003-2429-6320
- IdRef : 127109897
Sathishkumar Ramaswamy
- Function : Author
Laurent Renia
- Function : Author
Igor Resnick
- Function : Author
Raúl Rigo-Bonnin
- Function : Author
Carlos Rodríguez-Gallego
- Function : Author
Vanessa Sancho-Shimizu
- Function : Author
Anna Sediva
- Function : Author
Mikko R J Seppänen
- Function : Author
Mohammed Shahrooei
- Function : Author
Anna Shcherbina
- Function : Author
Ondrej Slaby
- Function : Author
Andrew L Snow
- Function : Author
Pere Soler-Palacín
- Function : Author
András N Spaan
- Function : Author
Ivan Tancevski
- Function : Author
Stuart G Tangye
- Function : Author
Ahmad Abou Tayoun
- Function : Author
Baykal Tulek
- Function : Author
Stuart E Turvey
- Function : Author
K M Furkan Uddin
- Function : Author
Mohammed Uddin
- Function : Author
Bénédicte Clément
- Function : Author
Yumiko Abe-Jones
- Function : Author
Saurabh Asthana
- Function : Author
Sharvari Bhide
- Function : Author
Carolyn S Calfee
- Function : Author
Sidney A Carrillo
- Function : Author
Suzanna Chak
- Function : Author
Zachary Collins
- Function : Author
David J Erle
- Function : Author
Gabriela K Fragiadakis
- Function : Author
Rajani Ghale
- Function : Author
Carolyn M Hendrickson
- Function : Author
Alejandra Jauregui
- Function : Author
Kirsten N Kangelaris
- Function : Author
Matthew F Krummel
- Function : Author
Charles R Langelier
- Function : Author
Tasha Lea
- Function : Author
Deanna Lee
- Function : Author
Aleksandra Leligdowicz
- Function : Author
Carolyn Leroux
- Function : Author
Raphael Lota
- Function : Author
Michael Matthay
- Function : Author
Viet Nguyen
- Function : Author
Ravi Patel
- Function : Author
Logan Pierce
- Function : Author
Priya Prasad
- Function : Author
Arjun Arkal Rao
- Function : Author
Ahmad Rashid
- Function : Author
Nicklaus Rodriguez
- Function : Author
Bushra Samad
- Function : Author
Cole Shaw
- Function : Author
Austin Sigman
- Function : Author
Kevin Tang
- Function : Author
Luz Torres Altamirano
- Function : Author
Alyssa Ward
- Function : Author
Andrew Willmore
- Function : Author
Michael R Wilson
- Function : Author
Prescott G Woodruff
- Function : Author
Laurent Abel
- Function : Author
Clotilde Allavena
- Function : Author
Claire Andrejak
- Function : Author
- PersonId : 1144520
- IdHAL : claire-andrejak
- ORCID : 0000-0002-9998-8578
- IdRef : 11107410X
François Angoulvant
- Function : Author
Cecile Azoulay
- Function : Author
Delphine Bachelet
- Function : Author
Marie Bartoli
- Function : Author
Romain Basmaci
- Function : Author
- PersonId : 1047428
- IdRef : 137467362
Sylvie Behilill
- Function : Author
Marine Beluze
- Function : Author
Nicolas Benech
- Function : Author
Dehbia Benkerrou
- Function : Author
Krishna Bhavsar
- Function : Author
Laurent Bitker
- Function : Author
Lila Bouadma
- Function : Author
Maude Bouscambert
- Function : Author
Pauline Caraux Paz
- Function : Author
Minerva Cervantes-Gonzalez
- Function : Author
Anissa Chair
- Function : Author
Catherine Chirouze
- Function : Author
- PersonId : 760630
- ORCID : 0000-0002-6150-2376
- IdRef : 058486186
Alexandra Coelho
- Function : Author
Hugues Cordel
- Function : Author
Camille Couffignal
- Function : Author
Sandrine Couffin-Cadiergues
- Function : Author
Eric D’ortenzio
- Function : Author
Etienne de Montmollin
- Function : Author
Alexa Debard
- Function : Author
Marie-Pierre Debray
- Function : Author
Dominique Deplanque
- Function : Author
Diane Descamps
- Function : Author
Mathilde Desvallée
- Function : Author
Alpha Diallo
- Function : Author
Jean-Luc Diehl
- Function : Author
Alphonsine Diouf
- Function : Author
Céline Dorival
- Function : Author
François Dubos
- Function : Author
Xavier Duval
- Function : Author
Philippine Eloy
- Function : Author
Vincent Enouf
- Function : Author
Olivier Epaulard
- Function : Author
Hélène Esperou
- Function : Author
Marina Esposito-Farese
- Function : Author
Manuel Etienne
- Function : Author
Denis Garot
- Function : Author
Nathalie Gault
- Function : Author
Alexandre Gaymard
- Function : Author
- PersonId : 1259371
- ORCID : 0000-0002-8194-6126
Jade Ghosn
- Function : Author
Tristan Gigante
- Function : Author
Morgane Gilg
- Function : Author
François Goehringer
- Function : Author
Jérémie Guedj
- Function : Author
Alexandre Hoctin
- Function : Author
Isabelle Hoffmann
- Function : Author
Ikram Houas
- Function : Author
Jean-Sébastien Hulot
- Function : Author
Salma Jaafoura
- Function : Author
Ouifiya Kafif
- Function : Author
Florentia Kaguelidou
- Function : Author
Sabrina Kali
- Function : Author
Younes Kerroumi
- Function : Author
Antoine Khalil
- Function : Author
Coralie Khan
- Function : Author
Antoine Kimmoun
- Function : Author
Fabrice Laine
- Function : Author
Cédric Laouénan
- Function : Author
Samira Laribi
- Function : Author
Minh Le
- Function : Author
Cyril Le Bris
- Function : Author
Sylvie Le Gac
- Function : Author
Quentin Le Hingrat
- Function : Author
Soizic Le Mestre
- Function : Author
Hervé Le Nagard
- Function : Author
Adrien Lemaignen
- Function : Author
Véronique Lemee
- Function : Author
François-Xavier Lescure
- Function : Author
Sophie Letrou
- Function : Author
Yves Levy
- Function : Author
Bruno Lina
- Function : Author
- PersonId : 837368
- ORCID : 0000-0002-8959-2123
- IdRef : 075685132
Guillaume Lingas
- Function : Author
Jean Christophe Lucet
- Function : Author
Moïse Machado
- Function : Author
Denis Malvy
- Function : Author
Marina Mambert
- Function : Author
Aldric Manuel
- Function : Author
France Mentré
- Function : Author
Amina Meziane
- Function : Author
Hugo Mouquet
- Function : Author
Jimmy Mullaert
- Function : Author
Nadège Neant
- Function : Author
Duc Nguyen
- Function : Author
Marion Noret
- Function : Author
Aurélie Papadopoulos
- Function : Author
Christelle Paul
- Function : Author
Nathan Peiffer-Smadja
- Function : Author
Vincent Peigne
- Function : Author
- PersonId : 1097695
- ORCID : 0000-0003-0699-8353
- IdRef : 122757793
Ventzislava Petrov-Sanchez
- Function : Author
Gilles Peytavin
- Function : Author
Huong Pham
- Function : Author
Olivier Picone
- Function : Author
Valentine Piquard
- Function : Author
Julien Poissy
- Function : Author
Oriane Puéchal
- Function : Author
Manuel Rosa-Calatrava
- Function : Author
- PersonId : 919324
- ORCID : 0000-0002-7559-9527
Bénédicte Rossignol
- Function : Author
Patrick Rossignol
- Function : Author
Carine Roy
- Function : Author
Marion Schneider
- Function : Author
Richa Su
- Function : Author
Coralie Tardivon
- Function : Author
Marie-Capucine Tellier
- Function : Author
François Téoulé
- Function : Author
Olivier Terrier
- Function : Author
- PersonId : 738296
- IdHAL : olivier-terrier
- ORCID : 0000-0001-9393-7684
- IdRef : 133418464
Jean-François Timsit
- Function : Author
- PersonId : 758651
- ORCID : 0000-0002-6063-7383
- IdRef : 077116313
Christelle Tual
- Function : Author
Sarah Tubiana
- Function : Author
Sylvie van der Werf
- Function : Author
- PersonId : 1202918
- IdHAL : sylvie-van-der-werf
- ORCID : 0000-0002-1148-4456
- IdRef : 070954534
Noémie Vanel
- Function : Author
Aurélie Veislinger
- Function : Author
Benoit Visseaux
- Function : Author
Aurélie Wiedemann
- Function : Author
Yazdan Yazdanpanah
- Function : Author
Abstract
Life-threatening ‘breakthrough’ cases of critical COVID-19 are attributed to poor or waning antibody response to the SARS-CoV-2 vaccine in individuals already at risk. Pre-existing autoantibodies (auto-Abs) neutralizing type I IFNs underlie at least 15% of critical COVID-19 pneumonia cases in unvaccinated individuals; however, their contribution to hypoxemic breakthrough cases in vaccinated people remains unknown. Here, we studied a cohort of 48 individuals (age 20-86 years) who received 2 doses of an mRNA vaccine and developed a breakthrough infection with hypoxemic COVID-19 pneumonia 2 weeks to 4 months later. Antibody levels to the vaccine, neutralization of the virus, and auto-Abs to type I IFNs were measured in the plasma. Forty-two individuals had no known deficiency of B cell immunity and a normal antibody response to the vaccine. Among them, ten (24%) had auto-Abs neutralizing type I IFNs (aged 43-86 years). Eight of these ten patients had auto-Abs neutralizing both IFN-α2 and IFN-ω, while two neutralized IFN-ω only. No patient neutralized IFN-β. Seven neutralized 10 ng/mL of type I IFNs, and three 100 pg/mL only. Seven patients neutralized SARS-CoV-2 D614G and the Delta variant (B.1.617.2) efficiently, while one patient neutralized Delta slightly less efficiently. Two of the three patients neutralizing only 100 pg/mL of type I IFNs neutralized both D61G and Delta less efficiently. Despite two mRNA vaccine inoculations and the presence of circulating antibodies capable of neutralizing SARS-CoV-2, auto-Abs neutralizing type I IFNs may underlie a significant proportion of hypoxemic COVID-19 pneumonia cases, highlighting the importance of this particularly vulnerable population.
Domains
ImmunologyOrigin | Publisher files allowed on an open archive |
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Licence |
Public Domain
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