With the advances in next-generation sequencing and data modelling, T-cell receptor and B-cell repertoires are now believed to provide biomarkers of disease and diagnostics in several immune related diseases as well as new tools for the development of new therapeutic targets. In the race of methods development, it is important to ensure the reliability of such complex biological component characterized by an uneven diversity. During this seminar, Encarnita Mariotti-Ferrandiz will her introduce recent comparative study that evaluated the performances of various molecular biology methods commonly used in the field for T-cell receptor repertoire study. Anne Eugster will further introduce plans from the AIRR-Community Biological Resources working group regarding B-cell receptor benchmarking.