COVID-19–associated Lung Microvascular Endotheliopathy: A “From the Bench” Perspective - Sorbonne Université Access content directly
Journal Articles American Journal of Respiratory and Critical Care Medicine Year : 2022

COVID-19–associated Lung Microvascular Endotheliopathy: A “From the Bench” Perspective

Lauren Rodriguez
  • Function : Author
Zachary A Matthay
  • Function : Author
Elliot Lloyd
  • Function : Author
Alexander T Fields
  • Function : Author
Roland J Bainton
  • Function : Author
Philip Kurien
  • Function : Author
Anita Sil
  • Function : Author
Carolyn S Calfee
  • Function : Author
Prescott G Woodruff
  • Function : Author
David J Erle
Carolyn Hendrickson
  • Function : Author
Matthew F Krummel
  • Function : Author
Charles R Langelier
  • Function : Author
Michael A Matthay
  • Function : Author
Lucy Z Kornblith
Judith Hellman
Sharvari Bhide
  • Function : Author
Carolyn S Calfee
  • Function : Author
Sidney A Carrillo
  • Function : Author
Suzanna Chak
  • Function : Author
David J Erle
  • Function : Author
Gabriela K Fragiadakis
  • Function : Author
Rajani Ghale
  • Function : Author
Jeremy Giberson
  • Function : Author
Pat Glenn
  • Function : Author
Ana Gonzalez
  • Function : Author
Carolyn Hendrickson
  • Function : Author
Alejandra Jauregui
  • Function : Author
Norman Jones
  • Function : Author
Kirsten Kangelaris
  • Function : Author
Serena Ke
  • Function : Author
Matthew F Krummel
  • Function : Author
Charles R Langelier
  • Function : Author
Tasha Lea
  • Function : Author
Deanna Lee
  • Function : Author
Aleskandra Lelidowicz
  • Function : Author
Raphael Lota
  • Function : Author
Michael A Matthay
  • Function : Author
Jeff Milush
  • Function : Author
Viet Nguyen
  • Function : Author
Ahmad Sadeed Rashid
  • Function : Author
Nicklaus Rodriguez
  • Function : Author
Austin Sigman
  • Function : Author
Kevin Tang
  • Function : Author
Luz Torres Altamirano
  • Function : Author
Alyssa Ward
  • Function : Author
Andrew Willmore
  • Function : Author
Michael Wilson
  • Function : Author
Prescott G Woodruff
  • Function : Author
Biniam Ambachew
  • Function : Author
Sarah Cary
  • Function : Author
Lauren Chalwell
  • Function : Author
Christopher Colwell
  • Function : Author
Chayse Jones
  • Function : Author
Clayton Josephy
  • Function : Author
Carolyn Hendrickson
  • Function : Author
Deanna Lee
  • Function : Author
Matthieu Legrand
  • Function : Author
Juan Carlos Montoy
  • Function : Author
Aaron E Kornblith
  • Function : Author
Philip Kurien
  • Function : Author
Brenda Nunez-Garcia
  • Function : Author
Viet Nguyen
  • Function : Author
John J Park
  • Function : Author
Arun Prakash
  • Function : Author
Brittany Robinson
  • Function : Author
India Shelley
  • Function : Author
Katherine D Wick
  • Function : Author

Abstract

Rationale: Autopsy and biomarker studies suggest that endotheliopathy contributes to coronavirus disease (COVID-19)associated acute respiratory distress syndrome. However, the effects of COVID-19 on the lung endothelium are not well defined. We hypothesized that the lung endotheliopathy of COVID-19 is caused by circulating host factors and direct endothelial infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
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Dates and versions

hal-04022303 , version 1 (09-03-2023)

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Jérémie Joffre, Lauren Rodriguez, Zachary A Matthay, Elliot Lloyd, Alexander T Fields, et al.. COVID-19–associated Lung Microvascular Endotheliopathy: A “From the Bench” Perspective. American Journal of Respiratory and Critical Care Medicine, 2022, 206, pp.961 - 972. ⟨10.1164/rccm.202107-1774oc⟩. ⟨hal-04022303⟩
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