Characteristics of subjective cognitive decline associated with amyloid positivity - Sorbonne Université
Journal Articles Alzheimer's & Dementia : the Journal of the Alzheimer's Association Year : 2021

Characteristics of subjective cognitive decline associated with amyloid positivity

Olin Janssen
  • Function : Author
  • PersonId : 1368956
Sylvia Villeneuve
  • Function : Author
Julius Popp
  • Function : Author
Chris Rowe
  • Function : Author
Steffen Wolfsgruber
  • Function : Author
Michael Heneka
  • Function : Author
Henning Boecker
  • Function : Author
Oliver Peters
  • Function : Author
Jonas Jarholm
  • Function : Author
Lorena Rami
  • Function : Author
Adrià Tort-Merino
  • Function : Author
Alexa Pichet Binette
  • Function : Author
Judes Poirier
  • Function : Author
Pedro Rosa-Neto
  • Function : Author
Jiri Cerman
  • Function : Author
Daniel Alcolea
  • Function : Author
Juan Fortea
  • Function : Author
M Belén Sánchez-Saudinós
  • Function : Author
Jarith Ebenau
  • Function : Author
Cornelia Pocnet
  • Function : Author
Marie Eckerström
  • Function : Author
Louisa Thompson
  • Function : Author
Victor Villemagne
  • Function : Author
Rachel Buckley
  • Function : Author
Samantha Burnham
  • Function : Author
Marion Delarue
  • Function : Author
Yvonne Freund-Levi
  • Function : Author
Åsa K Wallin
  • Function : Author
Inez Ramakers
  • Function : Author
Magda Tsolaki
  • Function : Author
Hilkka Soininen
  • Function : Author
Harald Hampel
  • Function : Author
Luiza Spiru
  • Function : Author
Betty Tijms
  • Function : Author
Rik Ossenkoppele
  • Function : Author
Frans R J Verhey
  • Function : Author
Frank Jessen
  • Function : Author
Pieter Jelle Visser
  • Function : Author
Stephanie J.B. Vos
  • Function : Author
M. Belén Sánchez-Saudinós
  • Function : Author

Abstract

Introduction: The evidence for characteristics of persons with subjective cognitive decline (SCD) associated with amyloid positivity is limited. Methods: In 1640 persons with SCD from 20 Amyloid Biomarker Study cohort, we investigated the associations of SCD-specific characteristics (informant confirmation, domain-specific complaints, concerns, feelings of worse performance) demographics, setting, apolipoprotein E gene (APOE) ε4 carriership, and neuropsychiatric symptoms with amyloid positivity. Results: Between cohorts, amyloid positivity in 70-year-olds varied from 10% to 76%. Only older age, clinical setting, and APOE ε4 carriership showed univariate associations with increased amyloid positivity. After adjusting for these, lower education was also associated with increased amyloid positivity. Only within a research setting, informant-confirmed complaints, memory complaints, attention/concentration complaints, and no depressive symptoms were associated with increased amyloid positivity. Feelings of worse performance were associated with less amyloid positivity at younger ages and more at older ages. Discussion: Next to age, setting, and APOE ε4 carriership, SCD-specific characteristics may facilitate the identification of amyloid-positive individuals.
Fichier principal
Vignette du fichier
Alzheimer s Dementia - 2021 - Janssen - Characteristics of subjective cognitive decline associated with amyloid.pdf (1.6 Mo) Télécharger le fichier
Origin Publication funded by an institution

Dates and versions

hal-04524946 , version 1 (28-03-2024)

Licence

Identifiers

Cite

Olin Janssen, Willemijn J Jansen, Stephanie Vos, Merce Boada, Lucilla Parnetti, et al.. Characteristics of subjective cognitive decline associated with amyloid positivity. Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2021, 18 (10), pp.1832-1845. ⟨10.1002/alz.12512⟩. ⟨hal-04524946⟩
10 View
9 Download

Altmetric

Share

More