Characteristics of subjective cognitive decline associated with amyloid positivity
Olin Janssen
(1)
,
Willemijn J Jansen
(1)
,
Stephanie Vos
(1)
,
Merce Boada
(2, 3)
,
Lucilla Parnetti
(4)
,
Tomasz Gabryelewicz
(5)
,
Tormod Fladby
(6)
,
José Luis Molinuevo
(7)
,
Sylvia Villeneuve
,
Jakub Hort
(8, 9, 10)
,
Stéphane Epelbaum
(11, 12)
,
Alberto Lleó
(13)
,
Sebastiaan Engelborghs
(14, 15)
,
Wiesje M van der Flier
(16)
,
Susan Landau
(17)
,
Julius Popp
,
Anders Wallin
(18)
,
Philip Scheltens
(16)
,
Marcel Olde Rikkert
(19)
,
Peter J Snyder
(20, 21)
,
Chris Rowe
(22)
,
Gaël Chételat
(23)
,
Agustin Ruíz
(2, 24)
,
Marta Marquié
(2, 24)
,
Elena Chipi
(4)
,
Steffen Wolfsgruber
,
Michael Heneka
,
Henning Boecker
,
Oliver Peters
,
Jonas Jarholm
,
Lorena Rami
,
Adrià Tort-Merino
,
Alexa Pichet Binette
,
Judes Poirier
,
Pedro Rosa-Neto
,
Jiri Cerman
,
Bruno Dubois
(11)
,
Marc Teichmann
(11)
,
Daniel Alcolea
,
Juan Fortea
,
M Belén Sánchez-Saudinós
,
Jarith Ebenau
,
Cornelia Pocnet
,
Marie Eckerström
,
Louisa Thompson
,
Victor Villemagne
,
Rachel Buckley
,
Samantha Burnham
,
Marion Delarue
,
Yvonne Freund-Levi
,
Åsa K Wallin
,
Inez Ramakers
,
Magda Tsolaki
,
Hilkka Soininen
,
Harald Hampel
,
Luiza Spiru
,
Betty Tijms
,
Rik Ossenkoppele
,
Frans R J Verhey
,
Frank Jessen
,
Pieter Jelle Visser
,
Stephanie J.B. Vos
,
M. Belén Sánchez-Saudinós
1
Maastricht University [Maastricht]
2 UIC - Universitat Internacional de Catalunya [Barcelona]
3 ISC - Instituto de Salud Carlos III [Madrid]
4 UNIPG - Università degli Studi di Perugia = University of Perugia
5 IO-PAN - Institute of Oceanology, Polish Academy of Sciences
6 Akershus University Hospital [Lørenskog]
7 IDIBAPS - Institut d'Investigacions Biomèdiques August Pi i Sunyer
8 University Hospital Motol [Prague]
9 UK - Univerzita Karlova [Praha, Česká republika] = Charles University [Prague, Czech Republic]
10 St. Anne’s University Hospital [Brno]
11 ICM - Institut du Cerveau = Paris Brain Institute
12 IM2A - Institut de la Mémoire et de la Maladie d'Alzheimer [CHU Pitié-Salpétriêre]
13 Hospital de la Santa Creu i Sant Pau
14 UA - University of Antwerp
15 VUB - Vrije Universiteit Brussel [Bruxelles]
16 VU - Vrije Universiteit Amsterdam [Amsterdam]
17 UC - University of California
18 Sahlgrenska Academy at University of Gothenburg [Göteborg]
19 Radboud University Medical Center [Nijmegen]
20 UiO - University of Oslo
21 URI - University of Rhode Island
22 Austin Health
23 INSERM - Institut National de la Santé et de la Recherche Médicale
24 CIBERNED - Centro de Investigacion Biomédica en Red sobre Enfermedades Neurodegenerativas
2 UIC - Universitat Internacional de Catalunya [Barcelona]
3 ISC - Instituto de Salud Carlos III [Madrid]
4 UNIPG - Università degli Studi di Perugia = University of Perugia
5 IO-PAN - Institute of Oceanology, Polish Academy of Sciences
6 Akershus University Hospital [Lørenskog]
7 IDIBAPS - Institut d'Investigacions Biomèdiques August Pi i Sunyer
8 University Hospital Motol [Prague]
9 UK - Univerzita Karlova [Praha, Česká republika] = Charles University [Prague, Czech Republic]
10 St. Anne’s University Hospital [Brno]
11 ICM - Institut du Cerveau = Paris Brain Institute
12 IM2A - Institut de la Mémoire et de la Maladie d'Alzheimer [CHU Pitié-Salpétriêre]
13 Hospital de la Santa Creu i Sant Pau
14 UA - University of Antwerp
15 VUB - Vrije Universiteit Brussel [Bruxelles]
16 VU - Vrije Universiteit Amsterdam [Amsterdam]
17 UC - University of California
18 Sahlgrenska Academy at University of Gothenburg [Göteborg]
19 Radboud University Medical Center [Nijmegen]
20 UiO - University of Oslo
21 URI - University of Rhode Island
22 Austin Health
23 INSERM - Institut National de la Santé et de la Recherche Médicale
24 CIBERNED - Centro de Investigacion Biomédica en Red sobre Enfermedades Neurodegenerativas
Sylvia Villeneuve
- Function : Author
Julius Popp
- Function : Author
Steffen Wolfsgruber
- Function : Author
Michael Heneka
- Function : Author
Henning Boecker
- Function : Author
Oliver Peters
- Function : Author
Jonas Jarholm
- Function : Author
Lorena Rami
- Function : Author
Adrià Tort-Merino
- Function : Author
Alexa Pichet Binette
- Function : Author
Judes Poirier
- Function : Author
Pedro Rosa-Neto
- Function : Author
Jiri Cerman
- Function : Author
Daniel Alcolea
- Function : Author
Juan Fortea
- Function : Author
M Belén Sánchez-Saudinós
- Function : Author
Jarith Ebenau
- Function : Author
Cornelia Pocnet
- Function : Author
Marie Eckerström
- Function : Author
Louisa Thompson
- Function : Author
Victor Villemagne
- Function : Author
Rachel Buckley
- Function : Author
Samantha Burnham
- Function : Author
Marion Delarue
- Function : Author
Yvonne Freund-Levi
- Function : Author
Åsa K Wallin
- Function : Author
Inez Ramakers
- Function : Author
Magda Tsolaki
- Function : Author
Hilkka Soininen
- Function : Author
Harald Hampel
- Function : Author
Luiza Spiru
- Function : Author
Betty Tijms
- Function : Author
Rik Ossenkoppele
- Function : Author
Frans R J Verhey
- Function : Author
Frank Jessen
- Function : Author
Pieter Jelle Visser
- Function : Author
Stephanie J.B. Vos
- Function : Author
M. Belén Sánchez-Saudinós
- Function : Author
Abstract
Introduction: The evidence for characteristics of persons with subjective cognitive decline (SCD) associated with amyloid positivity is limited.
Methods: In 1640 persons with SCD from 20 Amyloid Biomarker Study cohort, we investigated the associations of SCD-specific characteristics (informant confirmation, domain-specific complaints, concerns, feelings of worse performance) demographics, setting, apolipoprotein E gene (APOE) ε4 carriership, and neuropsychiatric symptoms with amyloid positivity.
Results: Between cohorts, amyloid positivity in 70-year-olds varied from 10% to 76%. Only older age, clinical setting, and APOE ε4 carriership showed univariate associations with increased amyloid positivity. After adjusting for these, lower education was also associated with increased amyloid positivity. Only within a research setting, informant-confirmed complaints, memory complaints, attention/concentration complaints, and no depressive symptoms were associated with increased amyloid positivity. Feelings of worse performance were associated with less amyloid positivity at younger ages and more at older ages.
Discussion: Next to age, setting, and APOE ε4 carriership, SCD-specific characteristics may facilitate the identification of amyloid-positive individuals.
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Origin | Publication funded by an institution |
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