Characteristics of subjective cognitive decline associated with amyloid positivity

Olin Janssen; Willemijn J Jansen; Stephanie Vos; Merce Boada; Lucilla Parnetti; Tomasz Gabryelewicz; Tormod Fladby; José Luis Molinuevo; Sylvia Villeneuve; Jakub Hort; Stéphane Epelbaum; Alberto Lleó; Sebastiaan Engelborghs; Wiesje M van der Flier; Susan Landau; Julius Popp; Anders Wallin; Philip Scheltens; Marcel Olde Rikkert; Peter J Snyder; Chris Rowe; Gaël Chételat; Agustin Ruíz; Marta Marquié; Elena Chipi; Steffen Wolfsgruber; Michael Heneka; Henning Boecker; Oliver Peters; Jonas Jarholm; Lorena Rami; Adrià Tort-Merino; Alexa Pichet Binette; Judes Poirier; Pedro Rosa-Neto; Jiri Cerman; Bruno Dubois; Marc Teichmann; Daniel Alcolea; Juan Fortea; M Belén Sánchez-Saudinós; Jarith Ebenau; Cornelia Pocnet; Marie Eckerström; Louisa Thompson; Victor Villemagne; Rachel Buckley; Samantha Burnham; Marion Delarue; Yvonne Freund-Levi; Åsa K Wallin; Inez Ramakers; Magda Tsolaki; Hilkka Soininen; Harald Hampel; Luiza Spiru; Betty Tijms; Rik Ossenkoppele; Frans R J Verhey; Frank Jessen; Pieter Jelle Visser; Stephanie J.B. Vos; M. Belén Sánchez-Saudinós

doi:10.1002/alz.12512

Journal Articles Alzheimer's & Dementia : the Journal of the Alzheimer's Association Year : 2021

Characteristics of subjective cognitive decline associated with amyloid positivity

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Olin Janssen

Function : Author
PersonId : 1368956

Maastricht University [Maastricht]

Willemijn J Jansen

Function : Author

Maastricht University [Maastricht]

Stephanie Vos

Function : Author

Maastricht University [Maastricht]

Merce Boada

Function : Author

Universitat Internacional de Catalunya [Barcelona]

Instituto de Salud Carlos III [Madrid]

Lucilla Parnetti

Function : Author

Università degli Studi di Perugia = University of Perugia

Tomasz Gabryelewicz

Function : Author

Institute of Oceanology, Polish Academy of Sciences

Tormod Fladby

Function : Author

Akershus University Hospital [Lørenskog]

José Luis Molinuevo

Function : Author

Institut d'Investigacions Biomèdiques August Pi i Sunyer

Sylvia Villeneuve

Function : Author

Jakub Hort

Function : Author

University Hospital Motol [Prague]

Univerzita Karlova [Praha, Česká republika] = Charles University [Prague, Czech Republic]

St. Anne’s University Hospital [Brno]

Stéphane Epelbaum

Function : Author

Institut du Cerveau = Paris Brain Institute

Institut de la Mémoire et de la Maladie d'Alzheimer [CHU Pitié-Salpétriêre]

Alberto Lleó

Function : Author

Hospital de la Santa Creu i Sant Pau

Sebastiaan Engelborghs

Function : Author

University of Antwerp

Vrije Universiteit Brussel [Bruxelles]

Wiesje M van der Flier

Function : Author

Vrije Universiteit Amsterdam [Amsterdam]

Susan Landau

Function : Author

University of California

Julius Popp

Function : Author

Anders Wallin

Function : Author

Sahlgrenska Academy at University of Gothenburg [Göteborg]

Philip Scheltens

Function : Author

Vrije Universiteit Amsterdam [Amsterdam]

Marcel Olde Rikkert

Function : Author

Radboud University Medical Center [Nijmegen]

Peter J Snyder

Function : Author

University of Oslo

University of Rhode Island

Chris Rowe

Function : Author

Austin Health

Gaël Chételat

Function : Author

Institut National de la Santé et de la Recherche Médicale

Agustin Ruíz

Function : Author

Universitat Internacional de Catalunya [Barcelona]

Centro de Investigacion Biomédica en Red sobre Enfermedades Neurodegenerativas

Marta Marquié

Function : Author

Universitat Internacional de Catalunya [Barcelona]

Centro de Investigacion Biomédica en Red sobre Enfermedades Neurodegenerativas

Elena Chipi

Function : Author

Università degli Studi di Perugia = University of Perugia

Steffen Wolfsgruber

Function : Author

Michael Heneka

Function : Author

Henning Boecker

Function : Author

Oliver Peters

Function : Author

Jonas Jarholm

Function : Author

Lorena Rami

Function : Author

Adrià Tort-Merino

Function : Author

Alexa Pichet Binette

Function : Author

Judes Poirier

Function : Author

Pedro Rosa-Neto

Function : Author

Jiri Cerman

Function : Author

Bruno Dubois

Function : Author

Institut du Cerveau = Paris Brain Institute

Marc Teichmann

Function : Author

Institut du Cerveau = Paris Brain Institute

Daniel Alcolea

Function : Author

Juan Fortea

Function : Author

M Belén Sánchez-Saudinós

Function : Author

Jarith Ebenau

Function : Author

Cornelia Pocnet

Function : Author

Marie Eckerström

Function : Author

Louisa Thompson

Function : Author

Victor Villemagne

Function : Author

Rachel Buckley

Function : Author

Samantha Burnham

Function : Author

Marion Delarue

Function : Author

Yvonne Freund-Levi

Function : Author

Åsa K Wallin

Function : Author

Inez Ramakers

Function : Author

Magda Tsolaki

Function : Author

Hilkka Soininen

Function : Author

Harald Hampel

Function : Author

Luiza Spiru

Function : Author

Betty Tijms

Function : Author

Rik Ossenkoppele

Function : Author

Frans R J Verhey

Function : Author

Frank Jessen

Function : Author

Pieter Jelle Visser

Function : Author

Stephanie J.B. Vos

Function : Author

M. Belén Sánchez-Saudinós

Function : Author

Abstract

Introduction: The evidence for characteristics of persons with subjective cognitive decline (SCD) associated with amyloid positivity is limited. Methods: In 1640 persons with SCD from 20 Amyloid Biomarker Study cohort, we investigated the associations of SCD-specific characteristics (informant confirmation, domain-specific complaints, concerns, feelings of worse performance) demographics, setting, apolipoprotein E gene (APOE) ε4 carriership, and neuropsychiatric symptoms with amyloid positivity. Results: Between cohorts, amyloid positivity in 70-year-olds varied from 10% to 76%. Only older age, clinical setting, and APOE ε4 carriership showed univariate associations with increased amyloid positivity. After adjusting for these, lower education was also associated with increased amyloid positivity. Only within a research setting, informant-confirmed complaints, memory complaints, attention/concentration complaints, and no depressive symptoms were associated with increased amyloid positivity. Feelings of worse performance were associated with less amyloid positivity at younger ages and more at older ages. Discussion: Next to age, setting, and APOE ε4 carriership, SCD-specific characteristics may facilitate the identification of amyloid-positive individuals.

Keywords

Alzheimer's disease amyloid cerebrospinal fluid positron emission tomography subjective cognitive decline

Domains

Neurons and Cognition [q-bio.NC]

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Alzheimer s Dementia - 2021 - Janssen - Characteristics of subjective cognitive decline associated with amyloid.pdf (1.6 Mo)

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https://hal.sorbonne-universite.fr/hal-04524946

Submitted on : Thursday, March 28, 2024-2:07:41 PM

Last modification on : Friday, May 17, 2024-6:54:03 PM

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hal-04524946 , version 1 (28-03-2024)

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Attribution - NonCommercial

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HAL Id : hal-04524946 , version 1
DOI : 10.1002/alz.12512
PUBMED : 34877782
PUBMEDCENTRAL : PMC9786747

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Olin Janssen, Willemijn J Jansen, Stephanie Vos, Merce Boada, Lucilla Parnetti, et al.. Characteristics of subjective cognitive decline associated with amyloid positivity. Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2021, 18 (10), pp.1832-1845. ⟨10.1002/alz.12512⟩. ⟨hal-04524946⟩

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Characteristics of subjective cognitive decline associated with amyloid positivity

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