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Journal Articles Annals of Neurology Year : 2021

Investigation of Autosomal Genetic Sex Differences in Parkinson's Disease

Lynne Krohn
Manuela Tan
  • Function : Author
Jennifer A Ruskey
  • Function : Author
Lasse Pihlstrøm
Mathias Toft
Jacobus J van Hilten
  • Function : Author
Johan Marinus
  • Function : Author
Claudia Schulte
  • Function : Author
Kathrin Brockmann
Manu Sharma
Ari Siitonen
  • Function : Author
Kari Majamaa
  • Function : Author
Johanna Eerola‐rautio
  • Function : Author
Pentti J Tienari
  • Function : Author
Donald G Grosset
  • Function : Author
Nick Wood
  • Function : Author
John Hardy
  • Function : Author
Ziv Gan‐or
Peter Heutink
  • Function : Author
Thomas Gasser
  • Function : Author
Huw R Morris
  • Function : Author
Alastair J Noyce

Abstract

Objective: Parkinson’s disease (PD) is a complex neurodegenerative disorder. Men are on average  1.5 times more likely to develop PD compared to women with European ancestry. Over the years, genomewide association studies (GWAS) have identified numerous genetic risk factors for PD, however, it is unclear whether genetics contribute to dis- ease etiology in a sex-specific manner.
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Dates and versions

hal-04538974 , version 1 (09-04-2024)

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Cornelis Blauwendraat, Hirotaka Iwaki, Mary B Makarious, Sara Bandres‐ciga, Hampton L Leonard, et al.. Investigation of Autosomal Genetic Sex Differences in Parkinson's Disease. Annals of Neurology, 2021, 90, pp.35 - 42. ⟨10.1002/ana.26090⟩. ⟨hal-04538974⟩
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