Alamethicin induced conductances in lipid bilayers. Part II. Decomposition of the observed (compound) process
Résumé
The formalism required for deriving probabilities of the states of a single (elementary) pore, formed by the action of the polypeptide alamethicin in a lipid bilayer membrane, from the observed states of a single (elementary) pore from the observed probabilities of the compound states of the ensemble of pores is developed. Although the analysis has been developed in the context of the evaluation of the statistical properties of pore formation in lipid bilayers, alamethicin being the pore former, the treatment is in fact generally applicable to all situations where the modelling is most readily cast in terms of the behaviour of a single elementary system whilst the experiment deals with ensembles of such systems.
The application of the formalism for the steady state is illustrated in the succeeding paper; empirical extensions to the rate processes are also illustrated.