Alamethicin induced conductances in lipid bilayers. Part III. Derivation of the properties of the elementary process from the (compound) observed process
Résumé
The formalism for the derivation of the probabilities of the states of a single (elementary) pore from the observed probabilities of the compound states of the ensemble of pores, developed in the preceding paper, is extended to cover the transition probabilities between states of the elementary pore. These procedures have been applied to the voltage controlled pore formation in lipid bilayers under the action of alamethicin. Drift in this system is shown to be due to the dependence of the trigger rate for pore creation/destruction on age. The properties of the elementary process are independent of age; the elementary process exhibits an upper reflecting state (in a statistical sense).