Forebrain Eml1 depletion reveals early centrosomal dysfunction causing subcortical heterotopia - Sorbonne Université
Article Dans Une Revue Journal of Cell Biology Année : 2024

Forebrain Eml1 depletion reveals early centrosomal dysfunction causing subcortical heterotopia

Donia Zaidi
Kaviya Chinnappa
Berfu Nur Yigit
Valeria Viola
Carmen Cifuentes-Diaz
Ammar Jabali
Ana Uzquiano
Emilie Lemesre
Franck Perez
Julia Ladewig
Julien Ferent
Nurhan Ozlu
Fiona Francis

Résumé

Mechanisms leading to abnormal distribution of neural progenitors during cortical development in the context of subcortical heterotopia associated with EML1 mutations remain unknown. Using a forebrain-specific mouse model and mutant human cells, this work innovatively demonstrates that by restoring microtubule function, abnormal progenitor distribution and heterotopic volume are significantly reduced.
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Dates et versions

hal-04721394 , version 1 (04-10-2024)

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Donia Zaidi, Kaviya Chinnappa, Berfu Nur Yigit, Valeria Viola, Carmen Cifuentes-Diaz, et al.. Forebrain Eml1 depletion reveals early centrosomal dysfunction causing subcortical heterotopia. Journal of Cell Biology, 2024, 223 (12), ⟨10.1083/jcb.202310157⟩. ⟨hal-04721394⟩
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