Seroprevalence and risk factors for HIV, HCV, HBV and syphilis among blood donors in Mali - Sorbonne Université Accéder directement au contenu
Article Dans Une Revue BMC Infectious Diseases Année : 2019

Seroprevalence and risk factors for HIV, HCV, HBV and syphilis among blood donors in Mali

Sidi Dienta
  • Fonction : Auteur
Mahamadou Cisse
  • Fonction : Auteur
Amadou B Diarra
  • Fonction : Auteur
Alhassane Ba
  • Fonction : Auteur
Mounirou Baby
  • Fonction : Auteur
Chad J Achenbach
  • Fonction : Auteur
Robert Murphy
  • Fonction : Auteur

Résumé

BACKGROUND: HIV, HBV and HCV remain a global public health concern especially in Africa. Prevalence of these infections is changing and identification of risk factors associated with each infection in Mali is needed to improve medical care. METHODS: We conducted a cross-sectional study of all individuals donating blood (n = 8207) in 2018 to the blood bank at university hospital in Bamako, Mali, to assess prevalence and risks factors associated with HIV, HBV, HCV and syphilis infections. RESULTS: HIV-seroprevalence was 2.16% and significantly increased with age, being married and decreasing education level. In multivariate analysis, after adjustements with age, marital status and geographical setting, only education level was associated with HIV-infection (OR, 1.54 [95% CI, 1.15-2.07], p = 0.016). HBsAg prevalence was 14.78% and significantly increased with to be male gender. In multivariate analysis, adjusting for age, marital status and type of blood donation, education level (OR, 1.17 [95%CI, 1.05-1.31], p = 0.02) and male gender (OR, 1.37 [95%CI, 1.14-1.65], p = 0.005) were associated with HBV-infection. HCV-prevalence was 2.32% and significantly increased with living outside Bamako. In multivariate analysis, adjusting for gender, age and education level, living outside Bamako was associated with HCV-infection (OR, 1.83 [95% CI, 1.41-2.35], p < 0.001). Syphilis seroprevalence was very low (0.04%) with only 3 individuals infected. Contrary to a prior study, blood donation type was not, after adjustments, an independent risk factor for each infection. CONCLUSIONS: Overall, HIV and HBV infection was higher in individuals with a lower level of education, HBV infection was higher in men, and HCV infection was higher in people living outside of Bamako. Compared to studies performed in 1999, 2002 and 2007 in the same population, we found that HIV and HCV prevalence have decreased in the last two decades whereas HBV prevalence has remained stable. Our finding will help guide infection prevention and treatment programs in Mali.
Fichier principal
Vignette du fichier
s12879-019-4699-3.pdf (706.69 Ko) Télécharger le fichier
Origine : Publication financée par une institution
Loading...

Dates et versions

inserm-02436849 , version 1 (13-01-2020)

Identifiants

Citer

Aude Jary, Sidi Dienta, Valentin Leducq, Quentin Le Hingrat, Mahamadou Cisse, et al.. Seroprevalence and risk factors for HIV, HCV, HBV and syphilis among blood donors in Mali. BMC Infectious Diseases, 2019, 19 (1), pp.1064. ⟨10.1186/s12879-019-4699-3⟩. ⟨inserm-02436849⟩
79 Consultations
62 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More