Acidic Osteoid Templates the Plywood Structure of Bone Tissue - Matériaux Hybrides et Nanomatériaux Access content directly
Journal Articles Advanced Science Year : 2023

Acidic Osteoid Templates the Plywood Structure of Bone Tissue

Guylène Costentin
  • Function : Author
Franck Artzner


Bone is created by osteoblasts that secrete osteoid after which an ordered texture emerges, followed by mineralization. Plywood geometries are a hallmark of many trabecular and cortical bones, yet the origin of this texturing in vivo has never been shown. Nevertheless, extensive in vitro work revealed how plywood textures of fibrils can emerge from acidic molecular cholesteric collagen mesophases. This study demonstrates in sheep, which is the preferred model for skeletal orthopaedic research, that the deeper non‐fibrillar osteoid is organized in a liquid‐crystal cholesteric geometry. This basophilic domain, rich in acidic glycosaminoglycans, exhibits low pH which presumably fosters mesoscale collagen molecule ordering in vivo. The results suggest that the collagen fibril motif of twisted plywood matures slowly through self‐assembly thermodynamically driven processes as proposed by the Bouligand theory of biological analogues of liquid crystals. Understanding the steps of collagen patterning in osteoid‐maturation processes may shed new light on bone pathologies that emerge from collagen physico‐chemical maturation imbalances.
Fichier principal
Vignette du fichier
Robin_AdvSci_2023.pdf (8.61 Mo) Télécharger le fichier
Robin_AdvSci_2023_SI.pdf (1.41 Mo) Télécharger le fichier
Origin Publication funded by an institution
Origin Files produced by the author(s)

Dates and versions

hal-04384750 , version 1 (10-01-2024)




Marc Robin, Chakib Djediat, Arnaud Bardouil, Niki Baccile, Camille Chareyron, et al.. Acidic Osteoid Templates the Plywood Structure of Bone Tissue. Advanced Science, 2023, pp.2304454. ⟨10.1002/advs.202304454⟩. ⟨hal-04384750⟩
199 View
29 Download



Gmail Mastodon Facebook X LinkedIn More