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Dernières publications
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Dylan Moutachi, Janek Hyzewicz, Pauline Roy, Mégane Lemaitre, Damien Bachasson, et al.. Treadmill running and mechanical overloading improved the strength of the plantaris muscle in the dystrophin‐desmin double knockout (DKO) mouse. The Journal of Physiology, In press, ⟨10.1113/JP286425⟩. ⟨hal-04643936⟩
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Medhi Hassani, Dylan Moutachi, Mégane Lemaitre, Alexis Boulinguiez, Denis Furling, et al.. Beneficial effects of resistance training on both mild and severe mouse dystrophic muscle function as a preclinical option for Duchenne muscular dystrophy. PLoS ONE, 2024, 19, ⟨10.1371/journal.pone.0295700⟩. ⟨hal-04501283⟩
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Antonio Atalaia, Dagmar Wandrei, Nawel Lalout, Rachel Thompson, Adrian Tassoni, et al.. EURO-NMD registry: federated FAIR infrastructure, innovative technologies and concepts of a patient-centred registry for rare neuromuscular disorders. Orphanet Journal of Rare Diseases, 2024, 19 (1), pp.66. ⟨10.1186/s13023-024-03059-3⟩. ⟨hal-04460667⟩
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Florent Porquet, Lin Weidong, Kévin Jehasse, Hélène Gazon, Maria Kondili, et al.. Specific DMPK-promoter targeting by CRISPRi reverses myotonic dystrophy type 1-associated defects in patient muscle cells. Molecular Therapy - Nucleic Acids, 2023, 32, pp.857 - 871. ⟨10.1016/j.omtn.2023.05.007⟩. ⟨hal-04287597⟩
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Caroline Le Guiner, T Larcher, A Lafoux, G Toumaniantz, S Webb, et al.. Characterization of the muscular and cardiac diseases of the DMSXL mouse model, a transgenic mouse model for Myotonic Dystrophy type 1. American Society of Gene & Cell Therapy, May 2023, LOS ANGELES, United States. ⟨hal-04096181⟩
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Dylan Moutachi, Mégane Lemaitre, Clément Delacroix, Onnik Agbulut, Denis Furling, et al.. Valproic acid reduces muscle susceptibility to contraction‐induced functional loss but increases weakness in two murine models of Duchenne muscular dystrophy. Clinical and Experimental Pharmacology and Physiology, In press, ⟨10.1111/1440-1681.13804⟩. ⟨hal-04146953⟩
Chiffres clés
136
Publications avec texte intégral
Open Access
53 %
Mots clés
ARN
Acetylcholinesterase deficiency
Therapy
Dilated cardiomyopathy
Heart
Cell culture model
Skeletal muscle
Muscular dystrophy
Astrocytes
DMPK
Gene Therapy
Humans
RNA splicing
RNA biology
CTG repeat contractions
Intermediate filament
Quantitative microdialysis
Myostatin
Maximal force
Glucocorticoid-receptor
CRISPR/Cas9
Myotonic Dystrophy Type 1
AAV
Trinucleotide Repeat Expansion
In vivo
Expression
Muscle
ACETYLCHOLINESTERASE
Thérapie génique
GABA
Motoneuron
GSK3
Desmin
CRISPRi
Cell model
CTG repeats
Glucocorticoids
Brain dysfunction
Long read sequencing
Myotonic dystrophy mouse models
Cardiac muscle
Oligodendrocyte
Gene therapy
Dystrophie Myotonique
Genotype phenotype correlation
CONGENITAL MYATHENIC SYNDROME
Glial cells
Aging
CTG repeat instability
Cytoskeleton
Neuron
Mouse model
PacBio
KNOCKOUT MICE
Myelin
Mouse models
Heart failure
Diaphragm
Mice
Dystrophie myotonique
Transgenic mouse model
Brain
Dynamin 2
Knockout
DMSXL mice
Antisense oligonucleotide
Glutamate
PCR
Myotonic Dystrophy type 1
Antisense oligonucleotides
Animals
Exercice
Transcriptomics
Central nervous system
Gene editing
Myotonic dystrophy type 1
Myotonic Dystrophy
Acetylcholinesterase knockout mouse
BIOLOGIE MOLECULAIRE
Oligodendrocytes
RNA interference
DM1
MBNL
Transgenic mouse
Autophagy
Astrocyte
Duchenne muscular dystrophy
Myotonic dystrophy
Fibrosis
Dystrophin
Exercise
Endurance training
Trinucleotide repeat expansion
Alternative splicing
Centronuclear myopathy
Acute coronary syndrome
Cell penetrating peptide
Male
CMS
Hypoxia