Interrelationships among asthma, atopy, rhinitis and exhaled nitric oxide in a population-based sample of children. - Sorbonne Université Access content directly
Journal Articles Clinical and Experimental Allergy Year : 2003

Interrelationships among asthma, atopy, rhinitis and exhaled nitric oxide in a population-based sample of children.

Abstract

BACKGROUND: Exhaled nitric oxide (eNO) has attracted increasing interest as a non-invasive marker of airway inflammation in asthma. However, little evidence exists on the influences exerted on eNO by the interrelations among atopic status, asthma and rhinitis. METHODS: Among the 1156 children who participated in a large-scale epidemiological survey on asthma and allergies (ISAAC II: International Study of Asthma and Allergies in Childhood Phase II) in the city of Clermont-Ferrand, 53 asthmatics without corticosteroid treatment and 96 non-asthmatics were invited to perform eNO and skin prick tests (SPTs) to 12 common allergens. RESULTS: Atopic asthmatic children had higher eNO than non-atopic asthmatic children (28.9+/-9.1 vs. 17.1+/-13.1 p.p.b.; P=0.0004) with a significant increase when one SPT or more are positive (26.5+/-7.8 vs. 17.1+/-13.1 p.p.b.; P=0.03). Similarly, non-asthmatic, atopic subjects had higher eNO than non-atopic subjects with a significant increase when two SPTs or more are positive (19.4+/-9.8 vs. 11.7 +/-6.7 p.p.b.; P=0.003). In the case of equal levels of positive SPTs (0, 1, >/=2), asthmatic children always had higher eNO than non-asthmatic ones. Furthermore, among non-asthmatic children, the eNO level increased only in atopics who had rhinitis (20.7+/-13 vs. 12.5+/-6.4 p.p.b. in atopic controls (subjects without rhinitis and asthma) and 12.3+/-6.6 p.p.b. in non-atopic controls; P=0.001), whereas among asthmatic children, eNO level increased in atopics independently of rhinitis (28.2+/-9.5 p.p.b. in those with rhinitis and 30.9+/-8.1 p.p.b. in those without) as well as in non-atopics with rhinitis (22.5+/-17.2 p.p.b.). CONCLUSIONS: Our data suggest that besides atopy and asthma, allergic rhinitis should also be taken into account in the assessment of eNO.
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Dates and versions

hal-00596419 , version 1 (27-05-2011)

Identifiers

  • HAL Id : hal-00596419 , version 1
  • PUBMED : 14616861

Cite

L. F. Jouaville, Isabella Annesi-Maesano, L. T. Nguyen, A. S. Bocage, M. Bedu, et al.. Interrelationships among asthma, atopy, rhinitis and exhaled nitric oxide in a population-based sample of children.. Clinical and Experimental Allergy, 2003, 33 (11), pp.1506-11. ⟨hal-00596419⟩
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