Smoking, CD45R0+ (memory), and CD45RA+ (naive) CD4+ T cells. - Sorbonne Université Access content directly
Journal Articles Am Rev Respir Dis Year : 1993

Smoking, CD45R0+ (memory), and CD45RA+ (naive) CD4+ T cells.


The relationship between smoking and percentages and counts of T-cell subsets, in particular CD45R0+ (memory) and CD45RA+ (naive) CD4+ lymphocytes, have been assessed in a sample of 311 middle-aged men working in the Paris area. Percentages of lymphocytes with the phenotypes CD4+, CD8+, CD4+CD45R0+, and CD4+CD45RA+ were determined using double immunofluorescence labeling. All cell counts, including CD4+CD45R0+, and CD4+CD45RA+ lymphocytes increased significantly with tobacco consumption, as did the percentages of lymphocytes with the CD4+CD45R0+ and CD4+ phenotypes. The increase in the percentage of lymphocytes with the CD4+CD45RA+ phenotype, although not significant, was similar to that observed in the percentage of CD4+CD45R0+ lymphocytes. When the proportions of CD4+ cells with the CD45R0+ or the CD45RA+ phenotype were considered, no specific modification of any of these two sub-populations was observed: the effect of smoking on memory and naive Cd4+ lymphocytes seemed to be equivalent.
No file

Dates and versions

hal-00596503 , version 1 (27-05-2011)


  • HAL Id : hal-00596503 , version 1
  • PUBMED : 8100408


M. Chavance, J. Y. Perrot, I. Annesi. Smoking, CD45R0+ (memory), and CD45RA+ (naive) CD4+ T cells.. Am Rev Respir Dis, 1993, 148 (1), pp.237-40. ⟨hal-00596503⟩
11 View
0 Download



Gmail Facebook X LinkedIn More