Relationships of haptoglobin level to FEV1, wheezing, bronchial hyper-responsiveness and allergy. - Sorbonne Université Access content directly
Journal Articles Clinical and Experimental Allergy Year : 1991

Relationships of haptoglobin level to FEV1, wheezing, bronchial hyper-responsiveness and allergy.

Abstract

The relationships of haptoglobin level to respiratory and allergic parameters have been assessed in an epidemiological study conducted in a working population surveyed twice 5 years apart. At the first survey conducted in 892 working men, haptoglobin level was significantly related to FEV1 (r = -0.18; P less than 0.001) and smoking habits. After adjustment for smoking, a history of wheezing was significantly related to lower haptoglobin level. A second survey conducted in 304 men of the original sample 5 years later confirmed that haptoglobin was related to FEV1 (r = -0.21; P less than 0.001) and that wheezing was significantly related to hypohaptoglobinaemia (lower decile; P = 0.04). Men who exhibited bronchial hyper-responsiveness to methacholine had haptoglobin levels 0.35 g/l higher than those who did not (P = 0.01). Haptoglobin level was unrelated to IgE level and skin prick tests. These results support the hypothesis of the role of inflammation in both lower lung function and bronchial hyper-responsiveness. They suggest that some heterogeneity exists within subjects with a history of wheezing.
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Dates and versions

hal-00596510 , version 1 (27-05-2011)

Identifiers

  • HAL Id : hal-00596510 , version 1
  • PUBMED : 1777829

Cite

F. Kauffmann, C. Frette, I. Annesi, M. P. Oryszczyn, M. F. Dore, et al.. Relationships of haptoglobin level to FEV1, wheezing, bronchial hyper-responsiveness and allergy.. Clinical and Experimental Allergy, 1991, 21 (6), pp.669-74. ⟨hal-00596510⟩
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