In utero exposure to parental smoking, cotinine measurements, and cord blood IgE. - Sorbonne Université Accéder directement au contenu
Article Dans Une Revue Journal of Allergy and Clinical Immunology Année : 1991

In utero exposure to parental smoking, cotinine measurements, and cord blood IgE.

Résumé

The relationship between parental smoking and cord blood IgE has been studied in a survey conducted in 99 unselected newborn infants with a sensitive tests for IgE and cotinine as a biologic marker to validate smoking data. For both cord blood cotinine and maternal urine continine creatinine ratio (CCR), significantly higher levels were observed for smokers compared to nonsmokers. Furthermore, among nonsmokers, passive smokers had significantly higher cotinine levels than true nonsmokers, which demonstrates that cord blood may be used to assess active as well as passive maternal smoking. No association was observed in this study between cord blood IgE and maternal smoking assessed by questionnaire (geometric means of cord blood IgE levels were 0.11 IU/ml for newborn infants of smoking mothers and 0.12 IU/ml for newborn infants of nonsmoking mothers). The same observations were drawn from the analysis of cord blood IgE and cotinine levels, with correlation coefficients of -0.005 for cord blood CCR and 0.003 for maternal CCR. Additional studies are needed to determine whether maternal smoking is causally related to cord blood IgE and by which mechanisms.
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Dates et versions

hal-00596515 , version 1 (27-05-2011)

Identifiants

  • HAL Id : hal-00596515 , version 1
  • PUBMED : 2045619

Citer

M. P. Oryszczyn, J. Godin, I. Annesi, G. Hellier, F. Kauffmann. In utero exposure to parental smoking, cotinine measurements, and cord blood IgE.. Journal of Allergy and Clinical Immunology, 1991, 87 (6), pp.1169-74. ⟨hal-00596515⟩
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