[Pulmonary infections with Mycobacterium xenopi in patients without HIV infection]. - Sorbonne Université Access content directly
Journal Articles Revue des Maladies Respiratoires Year : 2007

[Pulmonary infections with Mycobacterium xenopi in patients without HIV infection].

A. Dixmier
  • Function : Author
J. L. Meynard
  • Function : Author
V. Lalande
  • Function : Author


OBJECTIVE: To determine the incidence, clinical characteristics, microbiological features and outcome of Mycobacterium xenopi infections in patients attending a university hospital. METHODS: We reviewed the files of HIV-seronegative patients meeting ATS criteria for M. xenopi pulmonary infection between 1993 and 2004. RESULTS: Ten patients were studied (7 men, 60+/-27 years). All but one had underlying chronic health disorders (chronic lung disease, cancer, alcoholism, systemic steroid therapy). The clinical and radiological findings were those associated with tuberculosis. Acid-fast bacilli were detected by direct examination in 9 cases, and antituberculous treatment prescribed in 8 patients. Specific treatment was started an average of 60+/-25 days after sampling, and generally combined a fluoroquinolone, clarithromycin and rifampicin, with or without ethambutol, for a mean of 11.4 months (1-37 months). Five patients had surgical excision (diagnostic in 1 case). Four patients died of their underlying disease. Two patients recovered with antibiotics alone and three with antibiotics and surgery. One patient was lost to follow-up after five months. CONCLUSION: Pulmonary infection by M. xenopi is rare in HIV-seronegative patients. The prognosis depends mainly on the patient's underlying health status. Surgery is an important component of treatment.
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Dates and versions

hal-00597126 , version 1 (31-05-2011)


  • HAL Id : hal-00597126 , version 1
  • PUBMED : 17417167


A. Dixmier, J. L. Meynard, V. Lalande, B. Lebeau, C. Chouaïd. [Pulmonary infections with Mycobacterium xenopi in patients without HIV infection].. Revue des Maladies Respiratoires, 2007, 24 (3 Pt 1), pp.299-304. ⟨hal-00597126⟩
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