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Journal Articles Applied Physics Letters Year : 2014

Loading and release of internally self-assembled emulsions embedded in a magnetic hydrogel

Abstract

We have investigated drug loading and release from thermosensitive gel emulsions with external triggering by an alternating magnetic field (AMF) for on-demand drug delivery. Superparamagnetic iron oxide nanoparticles dispersed in gel emulsions were used to study the loading and release capabilities, with the stable nitroxide radical 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO) serving as the model drug. AMF activation gave similar results to temperature activation in a water bath at 37 C, showing that the principal effect of the AMF is a temperature increase without burst release. These results suggest that the system could play an important role in the development of advanced drug delivery.
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Dates and versions

hal-00939100 , version 1 (06-12-2023)

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Irena Milo Sevic, Samuel Guillot, Marin Tadic, Mathieu Duttine, Etienne Duguet, et al.. Loading and release of internally self-assembled emulsions embedded in a magnetic hydrogel. Applied Physics Letters, 2014, 104 (4), pp.043701. ⟨10.1063/1.4862811⟩. ⟨hal-00939100⟩
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