Tendon development and diseases

Ludovic Gaut 1, 2 Delphine Duprez 2, 1, *
* Corresponding author
1 LBD-E02 - Formation et réparation des muscles et des tendons = Muscle and tendon formation and repair
INSERM - Institut National de la Santé et de la Recherche Médicale : U1156, LBD - Laboratoire de Biologie du Développement
Abstract : Tendon is a uniaxial connective tissue component of the musculoskeletal system. Tendon is involved in force transmission between muscle and bone. Tendon injury is very common and debilitating but tendon repair remains a clinical challenge for orthopedic medicine. In vertebrates, tendon is mainly composed of type I collagen fibrils, displaying a parallel organization along the tendon axis. The tendon-specific spatial organization of type I collagen provides the mechanical properties for tendon function. In contrast to other components of the musculoskeletal system, tendon biology is poorly understood. An important goal in tendon biology is to understand the mechanisms involved in the production and assembly of type I collagen fibrils during development, postnatal formation, and healing processes in order to design new therapies for tendon repair. In this review we highlight the current understanding of the molecular and mechanical signals known to be involved in tenogenesis during development, and how development provides insights into tendon healing processes.
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Ludovic Gaut, Delphine Duprez. Tendon development and diseases. Wiley Interdisciplinary Reviews: Developmental Biology, Wiley, 2015, 5 (1), pp.5-23 ⟨10.1002/wdev.201⟩. ⟨hal-01190806⟩

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