Reduced naïve CD8+T-cell priming efficacy in elderly adults - Sorbonne Université Access content directly
Journal Articles Aging Cell Year : 2015

Reduced naïve CD8+T-cell priming efficacy in elderly adults


Aging is associated with impaired vaccine efficacy and increased susceptibility to infectious and malignant diseases. CD8 + T-cells are key players in the immune response against pathogens and tumors. In aged mice, the dwindling na€ ıve CD8 + T-cell compartment is thought to compromise the induction of de novo immune responses, but no experimental evidence is yet available in humans. Here, we used an original in vitro assay based on an accelerated dendritic cell coculture system in unfractioned peripheral blood mononuclear cells to examine CD8 + T-cell priming efficacy in human volunteers. Using this approach, we report that old individuals consistently mount quantitatively and qualitatively impaired de novo CD8 + T-cell responses specific for a model antigen. Reduced CD8 + T-cell priming capacity in vitro was further associated with poor primary immune responsiveness in vivo. This immune deficit likely arises as a consequence of intrinsic cellular defects and a reduction in the size of the na€ ıve CD8 + T-cell pool. Collectively, these findings provide new insights into the cellular immune insufficiencies that accompany human aging.
Fichier principal
Vignette du fichier
Briceno_2015_Reduced_naive.pdf (458.38 Ko) Télécharger le fichier
Origin : Publication funded by an institution

Dates and versions

hal-01218054 , version 1 (20-10-2015)





Olivia Briceño, Anna Lissina, Kerstin Wanke, Georgia Afonso, Amrei von Braun, et al.. Reduced naïve CD8+T-cell priming efficacy in elderly adults. Aging Cell, 2015, 15 (1), pp.14-21 ⟨10.1111/acel.12384⟩. ⟨hal-01218054⟩
352 View
159 Download



Gmail Facebook X LinkedIn More