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Journal Articles Mechanisms of Ageing and Development Year : 2015

MARK-AGE biomarkers of ageing

Alexander Bürkle
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Michel Salmon
Antti Hervonen
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Mikko Hurme
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Many candidate biomarkers of human ageing have been proposed in the scientific literature but in all cases their variability in cross-sectional studies is considerable, and therefore no single measurement has proven to serve a useful marker to determine, on its own, biological age. A plausible reason for this is the intrinsic multi-causal and multi-system nature of the ageing process. The recently completed MARK-AGE study was a large-scale integrated project supported by the European Commission. The major aim of this project was to conduct a population study comprising about 3200 subjects in order to identify a set of biomarkers of ageing which, as a combination of parameters with appropriate weighting, would measure biological age better than any marker in isolation.
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hal-01225170 , version 1 (05-11-2015)


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Alexander Bürkle, María Moreno-Villanueva, Jürgen Bernhard, María Blasco, Gerben Zondag, et al.. MARK-AGE biomarkers of ageing. Mechanisms of Ageing and Development, 2015, Biomarkers of Human Ageing, 151, pp.2-12. ⟨10.1016/j.mad.2015.03.006⟩. ⟨hal-01225170⟩
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