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Cellularized Cellular Solids via Freeze-Casting

Sarah Christoph 1 Julien Kwiatoszynski 2 Thibaud Coradin 1 Francisco M. Fernandes 1, *
* Corresponding author
1 MATBIO - Matériaux et Biologie
LCMCP - Laboratoire de Chimie de la Matière Condensée de Paris
Abstract : The elaboration of metabolically active cell-containing materials is a decisive step toward the successful application of cell based technologies. The present work unveils a new process allowing to simultaneously encapsulate living cells and shaping cell-containing materials into solid-state macroporous foams with precisely controlled morphology. Our strategy is based on freeze casting, an ice templating materials processing technique that has recently emerged for the structuration of colloids into macroporous materials. Our results indicate that it is possible to combine the precise structuration of the materials with cellular metabolic activity for the model organism Saccharomyces cerevisiae.
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Submitted on : Thursday, March 10, 2016 - 12:00:38 PM
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Sarah Christoph, Julien Kwiatoszynski, Thibaud Coradin, Francisco M. Fernandes. Cellularized Cellular Solids via Freeze-Casting. Macromolecular Bioscience, Wiley-VCH Verlag, 2016, 16 (2), pp.182-187. ⟨10.1002/mabi.201500319⟩. ⟨hal-01286119⟩



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