The review intends to draw the attention of researchers working in retinal degenerations on the fact that classical apoptosis, for example, apoptosis triggering caspase activation, may not be the main pathway of cellular demise in this tissue.Former work already showed the difficulty of proving the activation of apoptosis effectors in different models of retinal degeneration. However, these results were not really considered because of the lack of an alternative explanation for cell death. Nowadays, the description of many pathways of cellular demise is filling the gap and other forms of cell death are now described in the retina. The knowledge on the molecular mechanisms of cell death is very important for the development of new therapeutic strategies, as well as for the evaluation of cell death onset in retinal degeneration.