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Chemical diversity of calcifications in thyroid and hypothetical link to disease

Abstract : Even though calcifications in thyroid nodules constitute a common finding in imaging and histopathology, and also may occur in both benign and malignant thyroid disease, their clinical importance remains unclear. A way to establish a possible relationship between their presence and the associated pathology may be given through a precise description of their chemical composition. In order to attain this goal, last generation Field Effect Scanning Electron Microscopy (FE-SEM) and classical Fourier Transform Infra Red (FT-IR) experiments have been performed on thyroid calcifications. Calcifications corresponding to different pathologies have been considered, including Graves’ disease, papillary carcinoma or multinodular goiter. The complete set of experiments shows for the first time a chemical diversity of pathological calcifications but no correlation between the chemical composition of the pathological calcifications and the disease.
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Conference papers
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https://hal.sorbonne-universite.fr/hal-01329450
Contributor : Gestionnaire Hal-Upmc <>
Submitted on : Thursday, June 9, 2016 - 11:32:24 AM
Last modification on : Wednesday, October 14, 2020 - 4:13:09 AM

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  • HAL Id : hal-01329450, version 1

Citation

Muriel Mathonnet, Arnaud Dessombz, Dominique Bazin, Raphaël Weil, Frédéric Triponez, et al.. Chemical diversity of calcifications in thyroid and hypothetical link to disease. 50th Annual Scientific Meeting of the European Society for Clinical Investigation Paris, Apr 2016, Paris, France. pp.8.08. ⟨hal-01329450⟩

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