Vitamin D Status, Insulin Resistance, Leptin-To-Adiponectin Ratio in Adolescents: Results of a 1-Year Lifestyle Intervention

Abstract : AIM: We aimed to study the relationships between circulating 25-hydroxyvitamin D [25(OH)D], insulin resistance and leptin-to-adiponectin (L/A) ratio in Guadeloupean children and adolescents and to analyse the changes in 25(OH)D levels after a 1-year lifestyle intervention program. METHODS: 25(OH)D concentrations were measured via a chemiluminescence assay. Cardiometabolic risk factors, homoeostasis model assessment of insulin resistance (HOMA-IR), and adipokines were measured. The lifestyle intervention included dietary counselling, regular physical activity. RESULTS: Among 117 girls and boys (11–15 years old, 31.6% obese), 40% had vitamin D deficiency (25(OH)D levels < 20 ng/mL). With linear regression models where 25(OH)D and HOMA-IR acted as independent variables and age, sex, BMI, L/A ratio as covariates, 25(OH)D was significantly associated with HOMA-IR alone (P = 0.036). HOMA-IR was also associated with BMI z-score ≥ 2, L/A ratio and an interaction term BMI z-score ≥ 2*L/A ratio (P < 0.001 for all). After one year, in 78 children/adolescent, mean serum 25(OH)D increased significantly from 21.4 ± 4.9 ng/mL at baseline to 23.2 ± 6.0 after 1 year; P = 0.003 whereas BMI z-score, HOMA-IR and L/A ratio decreased significantly (P = 0.003, P < 0.001 and P = 0.012; respectively). CONCLUSION: The association between 25(OH)D and HOMA-IR, independently of obesity and the high prevalence of vitamin D deficiency should be considered in order to prevent the later incidence of T2DM. A healthy lifestyle including non-sedentary and outdoor activities could be a way for improving vitamin D status.
Type de document :
Article dans une revue
Open Access Macedonian Journal of Medical Sciences, 2016, 4 (4), pp.596-602
Liste complète des métadonnées

https://hal.sorbonne-universite.fr/hal-01427889
Contributeur : Gestionnaire Hal-Upmc <>
Soumis le : vendredi 6 janvier 2017 - 10:21:01
Dernière modification le : vendredi 31 août 2018 - 09:02:02

Lien texte intégral

Identifiants

  • HAL Id : hal-01427889, version 1
  • PUBMEDCENTRAL : PMC5175505

Collections

Citation

Christine Rambhojan, Laurent Larifla, Josiane Clepier, Elodie Bouaziz-Amar, Fritz-Line Velayoudom Cephise, et al.. Vitamin D Status, Insulin Resistance, Leptin-To-Adiponectin Ratio in Adolescents: Results of a 1-Year Lifestyle Intervention. Open Access Macedonian Journal of Medical Sciences, 2016, 4 (4), pp.596-602. 〈hal-01427889〉

Partager

Métriques

Consultations de la notice

78