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Journal articles
Vancomycin-Associated Cast Nephropathy
Yosu Luque
1, 2
Kevin Louis
1
Chantal Jouanneau
2
Sandrine Placier
2
Emmanuel Esteve
2
Dominique Bazin
3
Eric Rondeau
1, 2
Emmanuel Letavernier
4, 2
Alice Wolfromm
5
Clément Gosset
6
Anna Boueilh
7
Maren Burbach
7
Perrine Frère
2
Marie-Christine Verpont
2
Sophie Vandermeersch
2
Dominique Langui
8
Michel Daudon
2, 4
Vincent Frochot
2, 4
Laurent Mesnard
1, 2, *
*
Corresponding author
3
SMiLES - Spectroscopie, Modélisation, Interfaces pour L'Environnement et la Santé
LCMCP - Laboratoire de Chimie de la Matière Condensée de Paris
Emmanuel Esteve 2
Author
Dominique Bazin 3
Author
Eric Rondeau 1, 2
Author
Emmanuel Letavernier 4, 2
Author
Perrine Frère 2
Author
Marie-Christine Verpont 2
Author
Sophie Vandermeersch 2
Author
Dominique Langui 8
Author
1
Urgences néphrologiques et transplantation rénale [CHU Tenon] (4 rue de la Chine, Paris, 75020 - France)
- AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP) (France)
- CHU Tenon [APHP] (4 Rue de la Chine, 75020 Paris - France)
2
Des Maladies Rénales Rares aux Maladies Fréquentes, Remodelage et Réparation (Bâtiment Recherche - 4 rue de la Chine 75970 Paris Cedex 20 - France)
- UPMC - Université Pierre et Marie Curie - Paris 6 (4 place Jussieu - 75005 Paris - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1155 (101, rue de Tolbiac, 75013 Paris - France)
3
SMiLES - Spectroscopie, Modélisation, Interfaces pour L'Environnement et la Santé (France)
- LCMCP - Laboratoire de Chimie de la Matière Condensée de Paris (11 place Marcelin Berthelot 75231 Paris Cedex 05 - France)
- UPMC - Université Pierre et Marie Curie - Paris 6 (4 place Jussieu - 75005 Paris - France)
- CdF (institution) - Collège de France (France)
- CNRS - Centre National de la Recherche Scientifique : UMR7574 (France)
4
Service d'Explorations fonctionnelles multidisciplinaires [CHU Tenon] (France)
- AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP) (France)
- CHU Tenon [APHP] (4 Rue de la Chine, 75020 Paris - France)
5
Service d'immuno-hématologie pédiatrique [CHU Necker] (149 Rue de Sèvres, 75015 Paris - France)
- AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP) (France)
- CHU Necker - Enfants Malades [AP-HP] (149 Rue de Sèvres 75015 Paris - France)
6
Service d'Anatomie pathologique [CHU Saint-Louis] (France)
- AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP) (France)
- Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris] (200 rue du Faubourg Saint-Denis 75475 Paris (Nord) Cedex 10 - France)
7
Service de Néphrologie-Transplantation [CHU Saint-Louis] (France)
- AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP) (France)
- Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris] (200 rue du Faubourg Saint-Denis 75475 Paris (Nord) Cedex 10 - France)
8
ICM - Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (47-83 Boulevard de l'Hôpital 75651 Paris Cedex 13 - France)
- UPMC - Université Pierre et Marie Curie - Paris 6 : UM75 (4 place Jussieu - 75005 Paris - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1127 (101, rue de Tolbiac, 75013 Paris - France)
- CHU Pitié-Salpêtrière [AP-HP] (47-83 Boulevard de l'Hôpital, 75013 Paris - France)
- CNRS - Centre National de la Recherche Scientifique : UMR7225 (France)
Abstract : Vancomycin is a widely prescribed antibiotic, but the exact nature of vancomycin-associated nephrotoxicity is unclear, in particular when considering the frequent coadministration of aminoglycosides. We describe here the initial case of a 56-year-old woman with normal renal function developing unexplained ARF without hypovolemia after administration of vancomycin without coadministration of aminoglycosides. Studying the patient’s renal biopsy specimen, we ascertained that obstructive tubular casts composed of noncrystal nanospheric vancomycin aggregates entangled with uromodulin explained the vancomycin-associated ARF. We developed in parallel a new immunohistologic staining technique to detect vancomycin in renal tissue and confirmed retrospectively that deleterious vancomycin-associated casts existed in eight additional patients with acute tubular necrosis in the absence of hypovolemia. Concomitant high vancomycin trough plasma levels had been observed in each patient. We also reproduced experimentally the toxic and obstructive nature of vancomycin-associated cast nephropathy in mice, which we detected using different in vivo imaging techniques. In conclusion, the interaction of uromodulin with nanospheric vancomycin aggregates represents a new mode of tubular cast formation, revealing the hitherto unsuspected mechanism of vancomycin-associated renal injury.
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Journal articles
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https://hal.sorbonne-universite.fr/hal-01437592
Contributor : Gestionnaire Hal-Upmc <>
Submitted on : Friday, June 22, 2018 - 12:59:13 PM
Last modification on : Wednesday, September 23, 2020 - 4:33:20 AM
Long-term archiving on: : Monday, September 24, 2018 - 1:30:01 PM
Contributor : Gestionnaire Hal-Upmc <>
Submitted on : Friday, June 22, 2018 - 12:59:13 PM
Last modification on : Wednesday, September 23, 2020 - 4:33:20 AM
Long-term archiving on: : Monday, September 24, 2018 - 1:30:01 PM
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Identifiers
- HAL Id : hal-01437592, version 1
- DOI : 10.1681/ASN.2016080867
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LCMCP-SMILES | INC-CNRS | U1155 | ICM | LCMCP | CDF | CNRS | UPMC | SORBONNE-UNIVERSITE | SU-MEDECINE | SU-SCIENCES | PSL
Citation
Yosu Luque, Kevin Louis, Chantal Jouanneau, Sandrine Placier, Emmanuel Esteve, et al.. Vancomycin-Associated Cast Nephropathy. Journal of the American Society of Nephrology, American Society of Nephrology, 2017, 28 (6), pp.ASN.2016080867. ⟨10.1681/ASN.2016080867⟩. ⟨hal-01437592⟩
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