Simple and Specific Grafting of Antibacterial Peptides on Silicone Catheters - Sorbonne Université
Journal Articles Advanced Healthcare Materials Year : 2016

Simple and Specific Grafting of Antibacterial Peptides on Silicone Catheters

Vincent Humblot

Abstract

To fight against nosocomial infection initiated by colonization of medical devices, a strategy enabling the direct and fast functionalization of silicone surfaces is proposed. This strategy proceeds in a site-specific way using original hybrid silylated antibacterial peptides. This safe and up-scalable method guarantees a covalent and robust immobilization with the correct orientation of the bioactive moiety. Importantly it also avoids multi-step chemical modifications of the surface or multi-layer polymer coatings. As proof of concept, antibacterial silicone catheter has been prepared whose immediate and long term efficiency is superior by comparison to similar silver-embedded materials.

Dates and versions

hal-01547344 , version 1 (26-06-2017)

Identifiers

Cite

Coline Pinese, Said Jebors, Cécile Echalier, Patricia Licznar-Fajardo, Xavier Garric, et al.. Simple and Specific Grafting of Antibacterial Peptides on Silicone Catheters. Advanced Healthcare Materials, 2016, 5 (23), pp.3067 - 3073. ⟨10.1002/adhm.201600757⟩. ⟨hal-01547344⟩
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