A New Series of Succinimido-ferrociphenols and Related Heterocyclic Species Induce Strong Antiproliferative Effects, Especially against Ovarian Cancer Cells Resistant to Cisplatin

Abstract : Ferrociphenols are known to display anticancer properties by original mechanisms dependent on redox properties and generation of active metabolites such as quinone methides. Recent studies have highlighted the positive impact of oxidative stress on chemosensitivity and prognosis of ovarian cancer patients. Ovarian adenocarcinomas are shown to be an excellent model for defining the impact of selected ferrociphenols as new therapeutic drugs for such cancers. This work describes the syntheses and preliminary mechanistic research of unprecedented multitargeting heterocyclic ferrociphenols bearing either a succinimidyl or phthalimidyl group that show exceptional antiproliferative behavior against epithelial ovarian cancer cells resistant to cisplatin. Owing to the failure of the present pharmaceutical options, such as carboplatin a metallodrug based on Pt coordination chemistry, these species may help to overcome the problem of lethal resistance. Currently, ferrociphenolic entities generally operate via apoptotic and senescence pathways. We present here our first results in this new cyclic-imide series.
Type de document :
Article dans une revue
Journal of Medicinal Chemistry, American Chemical Society, 2017, 60 (20), pp.8358-8368. 〈https://pubs.acs.org/doi/10.1021/acs.jmedchem.7b00743〉. 〈10.1021/acs.jmedchem.7b00743〉
Liste complète des métadonnées

Littérature citée [39 références]  Voir  Masquer  Télécharger

https://hal.sorbonne-universite.fr/hal-01611795
Contributeur : Gestionnaire Hal-Upmc <>
Soumis le : vendredi 6 octobre 2017 - 12:21:51
Dernière modification le : vendredi 31 août 2018 - 09:03:53
Document(s) archivé(s) le : lundi 8 janvier 2018 - 14:40:28

Fichier

Pigeon_2017_A_new_series_of.pd...
Fichiers produits par l'(les) auteur(s)

Identifiants

Collections

Citation

Pascal Pigeon, Yong Wang, Siden Top, Feten Najlaoui, Maria Concepcion Garcia Alvarez, et al.. A New Series of Succinimido-ferrociphenols and Related Heterocyclic Species Induce Strong Antiproliferative Effects, Especially against Ovarian Cancer Cells Resistant to Cisplatin. Journal of Medicinal Chemistry, American Chemical Society, 2017, 60 (20), pp.8358-8368. 〈https://pubs.acs.org/doi/10.1021/acs.jmedchem.7b00743〉. 〈10.1021/acs.jmedchem.7b00743〉. 〈hal-01611795〉

Partager

Métriques

Consultations de la notice

262

Téléchargements de fichiers

31