Tyroscherin and tyroscherin analogs from Pseudallescheria boydii SNB-CN85 isolated from termite Termes cf. hispaniolae

Abstract : Two new tyroscherin derivatives: N-methyl-tyroscherone (2) and tyroscherin N,O-acetonide (3), as well as two known secondary metabolites tyroscherin (1) and pseurotin A (4), were isolated from a solid culture of the termite-borne fungus Pseudallescheria boydii SNB-CN85. The structures were elucidated by spectroscopic analysis and chemical modification. Compound 3 was synthesized from tyroscherin (1) in the free amine form by heating in deuterated acetone, followed by deuterium-proton exchange in MeOH. All compounds were tested for their antimicrobial activities on C. albicans and S. aureus, and 2 and 3 exhibited minimal inhibitory concentrations between 128 and 8 μg mL−1.
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Phytochemistry Letters, Elsevier, 2017, 22, pp.142-144. 〈10.1016/j.phytol.2017.09.013〉
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Jonathan Sorres, Charlotte Nirma, Morgane Barthélemy, Véronique Eparvier, Didier Stien. Tyroscherin and tyroscherin analogs from Pseudallescheria boydii SNB-CN85 isolated from termite Termes cf. hispaniolae. Phytochemistry Letters, Elsevier, 2017, 22, pp.142-144. 〈10.1016/j.phytol.2017.09.013〉. 〈hal-01613323〉

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