Tyroscherin and tyroscherin analogs from Pseudallescheria boydii SNB-CN85 isolated from termite Termes cf. hispaniolae - Sorbonne Université Access content directly
Journal Articles Phytochemistry Letters Year : 2017

Tyroscherin and tyroscherin analogs from Pseudallescheria boydii SNB-CN85 isolated from termite Termes cf. hispaniolae

Abstract

Two new tyroscherin derivatives: N-methyl-tyroscherone (2) and tyroscherin N,O-acetonide (3), as well as two known secondary metabolites tyroscherin (1) and pseurotin A (4), were isolated from a solid culture of the termite-borne fungus Pseudallescheria boydii SNB-CN85. The structures were elucidated by spectroscopic analysis and chemical modification. Compound 3 was synthesized from tyroscherin (1) in the free amine form by heating in deuterated acetone, followed by deuterium-proton exchange in MeOH. All compounds were tested for their antimicrobial activities on C. albicans and S. aureus, and 2 and 3 exhibited minimal inhibitory concentrations between 128 and 8 μg mL−1.
Fichier principal
Vignette du fichier
Revised article.pdf (506.39 Ko) Télécharger le fichier
Origin : Files produced by the author(s)
Loading...

Dates and versions

hal-01613323 , version 1 (09-10-2017)

Identifiers

Cite

Jonathan Sorres, Charlotte Nirma, Morgane Barthélemy, Véronique Eparvier, Didier Stien. Tyroscherin and tyroscherin analogs from Pseudallescheria boydii SNB-CN85 isolated from termite Termes cf. hispaniolae. Phytochemistry Letters, 2017, 22, pp.142-144. ⟨10.1016/j.phytol.2017.09.013⟩. ⟨hal-01613323⟩
164 View
164 Download

Altmetric

Share

Gmail Facebook X LinkedIn More