Catalyst-free three-component synthesis of highly functionalized 2,3-dihydropyrroles - Sorbonne Université Access content directly
Journal Articles Green Chemistry Year : 2018

Catalyst-free three-component synthesis of highly functionalized 2,3-dihydropyrroles

Abstract

An efficient synthesis of fully substituted 2,3-dihydropyrroles has been achieved in one step through the three-component reaction of amines, aromatic aldehydes and α-ketoamides. This atom-economical and catalyst-free reaction is highly stereoselective and generates in a single step underexplored heterocycles. These compounds were examined in an enzymatic assay that led to the identification of potent α-glucosidase inhibitors, thereby demonstrating the utility of this novel methodology in medicinal chemistry.
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Dates and versions

hal-01829592 , version 1 (04-07-2018)

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Dong Wang, Linna Li, Hairong Feng, Hua Sun, Fabrice Almeida-Veloso, et al.. Catalyst-free three-component synthesis of highly functionalized 2,3-dihydropyrroles. Green Chemistry, 2018, 20 (12), pp.2775-2780. ⟨10.1039/C8GC00987B⟩. ⟨hal-01829592⟩
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