LaAlO 3 :Cr 3+ , Sm 3+ : Nano-perovskite with persistent luminescence for in vivo optical imaging

M. Pellerin 1, 2 E. Glais 1, 2 T. Lecuyer 3 J. Xu 4 J. Seguin 3, 5 S. Tanabe 4 C. Chaneac 1 B. Viana 2 C. Richard 3
1 LCMCP - Laboratoire de Chimie de la Matière Condensée de Paris
2 PSL - PSL Research University
3 UTCBS - UM 4 (UMR 8258 / U1022) - Unité de Technologies Chimiques et Biologiques pour la Santé
4 Graduate School of Human and Environmental Studies
5 USPC - Université Sorbonne Paris Cité
Abstract : Persistent luminescence (PersL) nanoparticles offer attractive capabilities for in vivo imaging applications as an optical excitation of the nanoparticles outside the animal before injection is possible. Therefore, long-lasting emission of light allows performing in vivo imaging with high signal to noise ratio and with high sensitivity. Here we report the development of LaAlO3 (LAO) nano-perovskite doped with Cr3+ and Sm3+, the trivalent chromium cation being the recombination center, while Sm3+ is used to enhance the persistent properties. Nanoparticles are synthesized by co-precipitation method and are tailored to present deep red persistent luminescence at 734 nm due to the Cr3+: 2E(2G) → 4A2(4F) transition after UV excitation. The intense deep red PersL matches well with the first biological window (650–950 nm). These nanoparticles have been successfully functionalized with polyethylene glycol (PEG) and the stealth obtained nanoparticles were tested for the first time for imaging on small animal in order to have access to their in vivo biodistribution.
Keywords : Bioimaging Perovskite Persistent luminescence Nanoparticles
Document type :
Journal articles
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https://hal.sorbonne-universite.fr/hal-01922548
Contributor : Gestionnaire Hal-Upmc <>
Submitted on : Wednesday, November 14, 2018 - 3:48:41 PM
Last modification on : Wednesday, May 15, 2019 - 4:03:11 AM

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MATISSE | CNRS | ENSCP | PSL | UNIV-PARIS5 | PARISTECH | INC-CNRS | USPC | SORBONNE-UNIVERSITE | LCMCP | SU-SCIENCES

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M. Pellerin, E. Glais, T. Lecuyer, J. Xu, J. Seguin, et al.. LaAlO 3 :Cr 3+ , Sm 3+ : Nano-perovskite with persistent luminescence for in vivo optical imaging. Journal of Luminescence, Elsevier, 2018, 202 (Octobre 2018), pp.83 - 88. ⟨10.1016/j.jlumin.2018.05.024⟩. ⟨hal-01922548⟩

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